- Ketogenic Diets That provides Most of the Daily Calorie Intake from Fats Have Gained Considerable Attention As a Lifestyle Intervention for Managing Obesity and Diabetes.
- ESPITE ITS Popularity and EFFECTIVESS IN PROMOTING Short-TERM WEIGHT LOSS, SOME HUMAN AND ANIMAL STUDIES SUGGEST AN ADVERSE IMPACT OF A KETO DIET ON METABOLIC HEALTH.
- A New Long-Term Study driver in Mice Now Shows That a Keto Diet Causa Causa Increase in Blood Lipid (Fat) Levels, Excessive Fat Storage in the Liver, And Impaired Glucose Regulation.
- These results Raise Concerns About the use of a ket diet for the management of obesity and diabetes and underscore the need for a chantionary approach.
Ketogenic or Keto Diets Are High-Fat, Low-Carbohydrate Diets That Have Been Used To Manage Seizures and Promote Weight Loss.
However, Whether a Keto Diet is Safe Over a Long Duration for Managing Diabetes Or Obesity Remas Unclear.
A Recent Study Published in Science Advances shows that mice mintoined on a oto diet for almost a year Showed High Blood Lipid (Fat) Levels, Fatty Liver Disease, and an unpaid ability to regulate Blood Glucose (Sugar) Levels Due to insufficient insulin secretion.
The Keto Diet Was Effective in Inducing Weight Loss in Mice With Obesity But Still had a negative impact on metabolic Health.
One of the Study Authors, Amandine Chaix, PHD, An Assistant Professor of Nutrition and Integrative Physiology at The University of Utah, Noted That these Effects of the Keto diet on Glucose regulation were reversible after its discontinuation.
Chaix Told Medical News Today That the Study “Results Suggest that More Studies are Warrad in Humans to establish the cardiometabolic benefits and risks of prolonged (Keto diet) feeding.”
These Findings Underscore The Consideration of Long-Term Risks of A Keto Diet in the Clinic Lie IS Potential To Cause Weight Loss and The Need For Further Research in Animals and Humans.
What is a Keto diet?
The
While the amount of calories obtained from fats in a keto diet can vary from 70% to 90%, A Classic Keto Diet Involves 90% of the Daily Energy INTAKE IN THE FORM OF FATS. It work by forcing the body to use fats as a source of energy instead of glycogen.
The Body Breaks Down Ingested Carbohydrates into Glucose, Which Is The Stored As Glycogen in the Liver and Muscles. These glycogen stores are subsequently used to provide energy.
The Depletion of Glycogen Stores AFTER Prolonged Fasting or Consuming A Keto Diet Causes The Body to Break Down Fat Unto Ketone Bodies. These Ketone Bodies Can The Be used by the body as a source of Energy.
Studies in Rodent Models Have Generally Shown Thatgagenic Diet is Effective In Inducing Weight Loss, But A FEW
Notby,
MOROVER, The Effects of A Keto Diet on The Body’s Ability to Metabolize Carbohydrates and Mainintain Normal Blood Glucose Levels Are Not Well Understood, With Sub Sub Sub Studies Showing Improvements In Glucose Regulation And Others Showing
In the present Study, The Refectchers Aimed to Further examine the long-term impact of a ket on the metabolic Health of Mice.
Impact on Body Weight and Fat Metabolism
The present Study Looked at Mouse Models Maintened on Eithher A Keto Diet, A High-Fat Diet, Low-Fat-Moderrate-Protein Diet, or Low-Fat Diet. The Mice in the Keto Diet Group Were Mainted on A Classic Keto Diet that providated 90% of the Daily Cal Calies from Fat.
The High-Fat Diet Provide 60% of the Daily Calories from Fats and has been used to Mimic The Effects of Obesity in Rodent Models. The Two Control Groups consisting of Mice Mainted on a Low-Fat Diet, With Proteins Provinding Eithher 10% or 20% of the Daily Calories.
The Measured Long-Term Changes in the Metabolic Health of Male and Female Mice AFTER AT Least 27 and 15 Weeks, respective, from the Start of the Study.
WHILE MICE IN BYTHE KETO DIET AND HIGH-FAT DIET GROUPS SHOWED WEIGHT GAIN IN COMPARISON WITH THE LOW-FAT DIET GROUPS, THE MICE ON THE KETO DIET GAINED LESS WEIGHT THOSHOS IN THE HIGH-FAT DIET GROUP.
In Adionion, The Mice in the Keto Diet Group Had Higher Levels of Plasma Lipids or Fats, Triglycerides, Than The High-Fat Diet and Low-Fat Diet Groups. Plasma Cholesterol Levels Were Also Elevated in Both the High-Fat and Keto Groups.
This Profile of Elevated Plasma Lipids in the Keto Diet Group suggested A decline in liver function. FURTER EXAMINATION OF THE MICE IN THE KETO AND HIGH-FAT DIET GROUPS REVALED EXCESSIVE STORAGE OF FATS IN THE LIVER, OR FATTY LIVER DIRECT, AND LIVER INFLAMMATION. However, Female Mice in the Keto Diet Group Did Not Show Signs of Fatty Liver Disease.
Keto Diet: Impact on Blood Sugar Regulation
The Mice in the Keto Diet Group Also Showed Impaired Glucose Tolerance, Which refers to the body’s ability to use and store glucose, to Type of Sugar. Glucose Intolerance is Characterized by The Persistence of Higher Blood Glucose Levels after Meal.
Insulin is reluctant to Meal and facilitates The Uptake of Glucose by the Liver and Muscles. Inadequate Release of Insulin or The Lack of An Adamate Response of Tissues to Insulin Can Lead to Elevated Blood Sugar Levels Or Glucose Intolerance.
Glucose Intoleronce was observed in Mice in Both the Keto and High-Fat Diet Groups But Was More Pronounced in the Keto Diet Mice. The Mice in the High-Fat Diet Group Showed Insulin Resistance Due to Lack of Suficient Response to Insulin, WHEREAS THE MICE IN THE KETO GROUP DID NOT RELEASE SUFFFICIEN INSULIN TO NORMALIZE BLOOD GLUCOSE LEVELS.
To understand the mechanism underlying the inadequate insulin secretion in the mice on the ketch diet, The Refers Than Examined Changes in the islet cells of the pancreas that produces and secret insulin secret.
The Refund Found Evidence Suggesting A Dysfunction of Cellular Structures that are involved in the transport and relaase of insulin.
At The Same Time, However, Mice That Were Mainted on a Keto Diet for A Long Time Showed Improvements in Glucose Tolerance Within 4 Weeks After Switching to Low-Fat Diet.
How might to Keto Diet Affect Obesity?
To Understand The Effects of A Keto Diet On Individuals with Preexisting Conditions Like Obesity Or Diabetes, The Refers Examined The Impact of Feeding A Keto Diet To Mouse Models of Obesity.
WHILE A KETO DIET WAS ABLE TO INDUCE WEIGHT LOSS INSE MICE, THEY CONTINUED TO EXHIBIT HIGH BLOOD LIPID LIPID LEVELS AND IMPAIRED GLUCOSE REGULATION. Notby, Low-Fat Diet was More Effective in Inducing Weight Loss in The Mice With Obesity While Improving Blood Lipid Levels and Glucose Regulation.
In Other Words, Even Though A Keto Diet May Be Effective in Inducing Weight Loss In Obese Mice, It was Associated with Adverse Effects on Metabolic Health. In contrast, A Low-Fat Diet May Be More Effective Than A Keto Diet In Inducing Weight Loss While Improving Metabolic Health.
Do these weekends Also Apply to Humans?
A Salient Feature of This Study Was The Maintenance of the Animals On The Keto Diet for Almost A Year. Chaix Told Us:
“Our Diet Intervention Was Maintained for About A Year, which represents approximately One Third of a mouse’s lifespan, allowing US to assses long-term consequences of feeding a Keto diet versus a lot of than we could in humans.”
“
In Their Study, The Refectchers Note The Keto Diet They used in the Study Had Higher Levels of Fats Than Generally consumed by individuals following This Dietary Approach, Namely: 4 Grams (G) of Fat To 1 G of Carbohydrates And Protein.
“To address this, we also put mice on a high protein, high-fe-ketogenic diet which caused similar causes to Ketogogenic diet and thereby suggesting that Other High-Fat, Low-Carbohydrate Diets, Like What Many People Consume, May Also Metabolic Health If Our Mouss Models Recapitulate What Happens in Humans, ”Said The Study’s First Author, Molly Gallop, PHD.
Gallop Further Note, However, That “
“While there is evidence that hyperlipidemia is a side effect of a ketogenic diet for epilepsy treatment in children, and other studies in humans suggest that a ketogogenic diet diet unpairs the body’s ability to respond to glucose, Our Study Warrants More Research in Humans,” She Added.
