• While Past Studies Show That Adults Taking A LPG-1 Medication Can Lose Between 5-15% of Their Starting Body Weight, Other Research Reports that A Good Portion of that weight loss comes from Muscle Loss.
  • A New Study Says, via mouse Model, That Muscle Loss from LP-1 Medications Like Ozempic May Not Be As High as Recently Thought.
  • Refokes Also Found that the decrease in Lean Muscle Mass Was Not All From Skeletal Muscles, But From Other Body Tissues, Including the Liver.

REST Glucagon-Like peptide-1 agonist receiver (LPG-1) – A Class of prescription Drugs Originally used to Treat Type 2 Diabetes That Has Gained Popularity As a Method of Weight Loss.

Types of LPG-1 Medications Include Semaglutide, Sold Under The Brand Names Ozempic and Wegovy, and TirzepatideSold Under The Brand Names Zepbound and Mounjaro.

Past Studies Show That Adults Taking A LPG-1 Medication Can Lose Between 5-15% of Their Starting Body Weight Within One Year.

However, Oher Research Reports That About 25-39% Of that weight loss is from Muscle Loss.

Now, New Study Recently Published in the Journal Cell metabolism Says, via mouse model, that muscle loss from LPG-1 medications like ozempic May not be ace high as Recently Thought.

Refokes Also Found that the decrease in Lean Muscle Mass Was Not All From Skeletal Muscles, But From Other Body Tissues, Including the Liver.

Lean Muscle Mass Not Just From Skeletal Muscles

For This Study, Refrachers used to muse to determine how LP-1 medications Like Ozempic Focked Lean Muscle Mass.

UPON ANALYSIS, FOUND THAT OZEMPIC-REALED WEIGHT LOSS IN MICE SUBSULTED IN A LEAN MUSCLE MASS DECREASE OF ABOUT 10%, WHICH ISS THAN THAN SOME PRIORIES STUDIES REPORT.

Scientists Report That As The Mice Lost Weight, Sikeletal Muscles Did Decrease, While Other Muscles Stayed The Same. Refecchers State that the Muscle Mass Decree is a return to Baseline, as gain is usually Accompanied by a Gain in Skeletal Muscle.

Researchers Found Sub Mice Experienced to decree in Strength in Skeletal Muscles that Stayed Almost The Same Size.

Additionionally, Researchers Found That A Good Portion of the decree in Lean Muscle Mass Did Not Come From Skeletal Muscles, But rather other tissues in the body, Such as the Liver, which they report reduced in size by almost half. It is not undo the liver to decree in size during Weight loss, which can helic reduces person’s risk for fatty liver disease.

“If we want to really help the individuals who may be The Study Says In a Press Relay. “We have data in mice that suggest that things are not as straightforward as they might seem.”

Working with Dieitian While Taking Glp-1s

Medical News Today Spoke with Seth Kipnis, MD, FACS, FASMBS, Director of Bariatric and Robotic Surgery at Hackensack Meridian Jersey Shore University Medical Center in New Jersey, About This Study, Who Commented that A Drop in Lean Muscle Mass is Experience.

Som Muscle Loss is inevitable

“Any Patient with a restricted diet and poor nutrition/protein Will have a drop in muscle mass. The Key of Any Weight Loss Program, Surgical, Medical Or LPG-1 is Adequate Nutrition.
– Seth Kipnis, MD, Facs, Fasmbs

“More and More People Are Taking these medications on a regular basis,” I have continued. “They are working Well to Control Weight. We Showd Know The Side Effects That Can Be Caused In The Long So So Patients Can Be Counseled On How To Avoid Long-Term Issues.”

Kipnis Said He was like to see Better Long-Term Data As The Next Steps in This Research.

“And are Different Outcomes Found depending on the prescriber and the type of follow-up,” I have added. “It is Our Assumption that Specialists in Weight Management and Nutrition Will Have Better Outcomes than A Primary Care Doctor That Treats Every Disease. OBESITY IS A UNIQUE DISEAS

Human Trials Needed To Further Analyze Glp-1s and Muscle Loss

MNT Also Talked to Kais Rona, MD, A Bariatric arguon of Memorialcare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, CA.

“As a Physician Who has treated and continues to treat many patients with glyp-1 medications such as ozempic, I Found This Study remove intersting,” Rona Said. “Although The Data In This Study Cannot Be extrapolate Directly To Humans, It Does Shed Sub light on potentially Important Physiologic Effects of the Medication.”

“The decree in lean mass with glyp-1 use was associated with a lesser decreases in skeletal muscle mass and a greater decree in the size of metabolically active organs such as the Liver. Decree in Liver Mass in Patients Undergoing Weight Loss Surgery, Which Often Leads to beneficial Health Effects.
– Kais Rona, MD

“It’s Extremely Important to continue to study the potential Side Effects, including the loss of lean muscle mass, Associated with Glp-1 medications as it can have Major Effects on Our Healthcare System As a Whole,” Rona Added. “Furthermore, We Need to continue Broaden Our Understanding of the Physiologic Effects of these Medications to optimize Patient Safety and Overall Outcomes.”

Rona Said The Next Best Research Step Would Be To Perform Randomized-Controlled Trials in Humans To Further Analyze The Effects of LPG-1 Medications on Lean Mass As Well As Skeletal Muscle Mass.

“IT WOULD BE IMPORTANT TO EVALUATE ITS EFFECTS ON MUSCLE STRENGTH AS WELL AS FUNCTION,” HE ADDED. “Also to Determine Whether Certain Areas of the Body Are More susceptible to Muscle Loss as Well as Identifying Preventive Strategies to Combat Muscle Loss.”