- One Big Area of concern For Users of LPG-1 Medications Such as Ozempic and Wegovy is Preventing Muscle Loss During Weight Loss.
- Salk Institute Researchers have identified that the protein bcl6 is key in mainting muscle mass.
- Their Research in Mice Reveared That Boosting BCl6 Levels Restors Muscle Mass and Strength, Offering Hope for LPG-1 users and Others prone to muscle deterioration.
- This Discovery Could Lead to Innovative Treatments for Conditions Like Aging, Cancer Cachexia, and Obesity-Related Muscle Loss While Opening New Doors For Weight Management Strategies.
In the United States, Roughly
However, these drarugs do not distinguish Between fat and muscle loss, with muscle accounting for
This Raises The Question: How can we prep pounds without the essential muscle?
In Their Study, Published in Proceedings of the National Academy of SciencesScientists Reveared That Mice with Reduced Bcl6 Levels Experienced Significant Declines in Muscle Mass and Strength While Increasing BCl6 Effectively Restored Tohese Losses.
The Findings suggest that combining glp-1 medications with a BCl6-Enhancing Drug Could Help Prevent Muscle Loss.
First Author Hunter (HUI) Wang, PHD, Postdoctoral Felow at The Salk Institute for Biological Sciences, Told Medical News Today That their Research Reveled That “The Transcriptional Repressor Bcl6 is required to Maintain Muscle Mass and Strength by Regulating Muscle Gene Expression, Specially During Changes in Nutritional Status.”
“In Simple Terms, We Found BCl6 Helps Muscles Stay Strong By Coordinating Growth and Nutrient Signals. WHEN BCL6 LEVEL DROPS, Such As During Prolonged Fasting, Muscle Starts to Lose Mass and Strength. Conversley, Boosting BCl6 Levels with Gene Therapies RESTORES MUSCLE MASS AND STENGTH IN PRECLINICAL STUDIES. ”
– Hunter (hui) wang, pHD
How Hunger Hormones Control Growth
WHEN YOU GO TOO Long Without Eating, Your Body Estrars A Fasted State.
During This Time, Your Stomach releases Hormone street ghrelin, which signals your brain that you’re Hungry. In Response, Your Brain produces Growth Hormone.
This Hormone plays an important role in Maintaining Your Body’s Growth and Metabolism by acting on Varyus Cells, Tissues and Organs.
WHEN Growth Hormone Reaches Cells, It Stimulates The Production of A Protein Calleed Insulin-Like Growth Factor 1 (IGF1), which is Essential for Muscle Growth.
However, The Amount of IGF1 produced is Tightly Regulated by a Network of Proteins. One of these Proteins, SOCS2, Slows Down the Production of IGF1.
If there isn’s aough socs2, IGF1 Levels Can Become Uncontrollable, Leading to Conditions Like Gigantism (Excessive Growth).
On the other hand, to a lot of socs2 reduces IGF1 Levels, resulting in smaller body size and Weaker Muscles.
While Socs2 is an important part of the process, it is not The Whole Story.
Scientists at The Salk Institute Wanned to Learn More About Howth Hormone and IGF1 AFFECT MUSCLE Maintenance, Specially to Prevent Rapid Muscle Loss.
By Analyzing A Large Database of Human Tissue Samples, They Found That Muscle Cells Contain High Levels of A Protein Called Bcl6, Suggesting It May Also Play A Significant Role In Regulating Musle Health and Strength.
This Research Provides New Insights into How Various Factors Control Muscle Growth and Maintenance, Which Could Help Develop Better Ways to Prevent Muscle Loss in The Future.
Underestanding bcl6 as a regulator in muscle maintenance
To investigate BCl6’s role in muscle mainnance, Refrachers Combase Mice with and Without Functional Bcl6 Proteins.
Mice Lacking Bcl6 Showed at 40% Reduction in Muscle Mass Combase To Healthy Mice, and Their Remaining Muscle was Structurally and Functionally Impaired.
However, Increasing BCl6 Expression in the Muscles of these Mice Successfully Restored Bush Muscle Mass and Strength.
In Adionion, When Normal Mice Were Compared to Those Who Fasted Overnight, The Fasting Mice Had Lower Bcl6 Levels in their muscles.
This demonstrated that bcl6 plays a Key Role in Muscle Maintenance.
But how? FURTER EXPERIMENTS REVALED THE MECHANISM AT WORK.
Fasting Triggers The Release of Growth Hormone, Which reduces BCl6 Levels in Muscle Cells. BCl6 Regulates Socs2, to decrease in bcl6 leads to a drop in socs2.
Normal Conditions, BCL6 Reure proper socs2 Expression, which, in turn, controls the production of IGF1.
Without BCl6, This Regulation Breaks Down, Cash2 Levels to Drop So Significantly That IGF1 Production Slows Dramatically, Resulting in Smaller, Weeker Muscles.
Is a new treatment on the horizon?
For LPG-1 users aiming to luse weight without sacrificing muscle mass, a BCl6-Boosting Injection miGHT BECOME Available in the future.
Meanwhile, The Refectchers Intend to Explore How prolonged fasting impacts bcl6 Levels and muscle mainnance.
Speaking to Medical News TodaySenior Author and Salk Professor Ronald Evans, Phd Said That “MainTINING MUSCLE MASS IS CRITICAL TO PHYSICAL STREGTH, METABOLIC FLEXIBILITY, AND QUALITY OF LIFE.”
“This Study Highlights BCl6 as a potential Therapeutic Target for Muscle Loss Due to Aging, Cancer Cachexia, Obesity and Complications from ITS TREATMENT (EG, LPG-1 recipient Agonists), Which Opened Doors for MANY PATIENTS EXPERIENCING MUSCLE WASTING.”
– Ronald Evans, PHD
Mark A. Anton, MD, FACS, Medical Director AT Slimz Weightlos, Not Involved in This Research, Told MNT That “This Study Highlights The Intricate Relationship Between Muscle Mass Regulation and Nutritional State, Potentially Offering New Insights into Muscle Preservation Strategies During Weight Loss.”
Mir Ali, MD, Board Certified General Get Complex The Body’s Mechanisms of Muscle Regulation, and How the Expression of Certain Chemicals Can Affect This. “
“Presenting Muscle Mass When Trying to Lose Fat is very important. Not only is muscle needy for normal function, Having More Muscle Mass Increases Energy Expenditure and Helps Keep Weight Off. If Further Research Can Show A Way To Increase The Expression of Muscle Building Chemicals, It May Be Another Adjunct to Help People Lose Weight and Preserve Muscle. ”
– Mir Ali, MD
