- DEVELOPING Gray Hair Is Common with Increaseing Age, Although Sub People Want To Avoid Tohese Hair Changes.
- One Recent Study in Mice Found That Internal and External Treatments With The Antioxidant Luteolin Helped Minimize Hair Graying.
- Future Research Can confirm if luteolin have similar Effects in People, But the Study Does Highlight Another Benefit of the antioxidant.
Is There Anything We Can Do To Prevent Gray Hairs? Experts are intersted in discovering the anxweer to that Question.
One Study Published in Antioxidants Explore How Three Antioxidants AFFFEED GRAY HAIR OUTCOMES IN MICE: HESPRETIN, GODMETIN, AND LUTEOLIN. While The Antioxidants Hesperetin and Godmetin Did Not Mitigate Hair Graying, Luteolin Did.
With Confirmation of Future Research, People May Use Luteolin to Prevent Gray Hires in the Future.
Comparising 3 antioxidants for hair graying
This Research Used Mice Created to Develop Gray Hair Be Age In A Way That Is Comparable To How People Develop Gray Hair.
The Authors of This Study First Explanin Implain Aspects of Whats Place In these Mice When Hair Turns Gray. There are two important types of stem cells in the bulge of the Hair Follicles: Keratinocyte Stem Cells and Follicular Melanocular Stem Cells. The Keratinocyte Stem Cells Experience A Decree In
They Note That If Experts Cá Find A Way To Suppress This Process, We Could Potentially Minimize Hair Graying. One potential candidate they were intersted in was luteolin, Flavonoid Found in Plants Like Parsley and Celery.
For This Research, The Mice Received Internal and External Luteolin Treatments Daily for Sixteen Weeks. Another Group of Mice Received External Hesperetin or Godmetin Treatments for 16 Weeks.
There Were Notable Effects for the Mice Who Received External Lutaolin. First, Researchers Obsthed A Decree in Cells with Certain Marker, which suggesta that the luteolin treatment support the aging of keratinocyte stem cells.
They Further Observed to Lower Percentage of Gray Hairs Among The Mice Treated With Luteolin. This and Other Observations Suggesta Duteolin Helped To Fix The Signaling Between The Endothelins in Keratinocyte Stem Cells and the Endothelin Receivers In the Melanocyte Stem Cells, Leading To Fewer Gray Hairs.
In contrast, external treatments with hesperetin and godmetin did not apply to affection Hair Graying.
Internal Luteolin Treatments Also Suppressed Hair Graying. The results suggested that luteolin did so in a Way similar to external luteolin treatments. However, The Treatment With Internal Lutaolin had Weaker Effect Than External Treatments.
Could luteolin be the solution to developing gray hair?
Refecchers Also Analyzed The Effect of Luteolin on Human Skin Keratinocytes. Luteolin Helped to decree The Transcript Expression Levels of An Aging Marker While Increasing The “Transcript Expression Level of Endothelin-1.” The Authors Note That This May indicate that endothelin-1 signaling in keratinocytes is involved in “Mediaing the Effects of Lotolin.”
Researchers Also Wanhed To Test How Oxidative Stress Promoted Hair Graying and If Luteolin Coud Offer Benefits in This Situation.
They test wild Mice Who Received Tert-Butyl Hydroperoxide Developed Gray Hair, But Mice Also Treated with Luteolin Experienced Less Hair Graying. These results suggest that in the Author’s Model Mice, Hair Graying May Be reduced by Decreating Oxidative Stress.
The Study’s Findings Support The Idea That Luteolin May Become An Effective Way To Minimize Gray Hair.
“We have Found a Drug Candidate to Prevent Hair Graying, which is off consider Negative Symbol of Aging. This Study Demonstrared That Luteolin, Natural Antioxidant, Can Suppress Hair Graying in Model Mice. OUR Findings Suggest that Luteolin Could Be a Viable candidate for developing therapeutic interventions aimed at mainting original hay color. ”
– Study Author Masashi Kato, MD, PHD, Speaking To Medical News Today
Study Limitations
This Research was only dried in Mice and Human Cells, So it’s Unclear if Luteolin Would have the Same Impact in People. Two of the Authors Note Competing Financial Interests, and also could conflicts have impact the results.
Future Research Can confirm If Luteolin Helps Minimize Gray Hairs in People As Well Amounts and Routes May Be Most Effective. The Authors Also Note That More Research Will Need to Be Done To Determine Safe Dosages For People.
TC Theoharides, PhD, MD, director of the molecular Immunopharmacology and Drug Discovery Laboratory in Boston, Massachusetts, Who has studied luteolin but Who was not involved in the study, note that “age are issues with using before compounds, and the most important is that luteolin is yellow. So, on a mouse you might be uble to put on a lot of you want. On A Human, It Will Be a Little Tricky. ”
Kato Note The Following About Continued Research:
“Research on Age-Related Changes, Including Prevention of Hair Graying, Is A Long-Term Process. Identifying Luteolin’s Anti-Graying Effects May Mark A Step forward in Anti-Ag Research. With Further Confirmation in Humans, Effective Strategies for Preventing and Treating Gray Hair Could Become A reality. ”
The Question of Why Remains Unnswered
This Study Also Does Not Exigin Why Exactly Luteolin Had the Effects It Did in The Study While Hesperetin and Godmetin Did Not. Additional Research Into the Underlying Mechanisms Involved in All Aspects of the Study Will Likely Be Useful.
Theoharids Note The Following Components of What Future Research Could Address:
“Following Up on this Paper is Worthwhile If Subsone has the melt to do it… I was not needed Jump Jump into Clinical Study. I WOLD WANT TO ASSESS AND GET A BETTER MODEL THAT BEST REFLECTS HUMANS … (Next) eat up with a Better preparation of luteolin, as I said, that doesn’t Have color and is More Likely to reach where you want it to reach. And Then Potentially, Find Out If there are populans, for whatver reason how to tour Gray Earlier than not so so that you might have to more homogeneous population to work with shrould you go into (a) clinical pilot trial.
Luteolin’s Health Benefits
This Research Emphasizes Another Potential Benefit of Luteolin, Adding to the List of Possible Benefits. For Example, Luteolin May Help with Pain Management and Could Potentially Help with Cancer Treatment. IT May Also Have Cardioprotective and Neuroprotective Benefits.
People Seeking to Get More Luteolin Have a Number of Food Sources to Choose From and Can Increase Luteolin Consumption with Appropriate Guidance.
Registered Dieitian Nutritionist Karen Z. Berg, MS, RD, CSO, CDN, WHO WAS ALSO NOT INVOLVED IN THE STUDY, SHARED GREAT FOOD SOURCES OF LUTEOLIN WITH Medical News Today.
Sources of Luteolin
“Luteolin is an antioxidant in many plant foods that has anti-inflammatory properties as well. Radicchio you have The Highest Amount of Luteolin, Followed by Many Green Peppers, Including Sweet Green Peppers, Hot Peppers, Serrano Peppers and Jalapeno Peppers. Arthokes, Pumpkin, and Cery Also Have Luteolin. ”
– Karen Z. Berg, MS, RD, CSO, CDN
“It is important to note though that the density of luteolin in each food varies greatly on the way the produces was Grown. Like Other Flavonoids, It is best to get This One Through Foods rather Than Supplements or Powders, ”She Added.
