- Type 2 diabetes is Characterized by Raised Blood Glucose Levels, which can increase the Risk of Cardiovascular Disease.
- A New Study Has Found That People with Type 2 Diabetes Who Ingested Ketones Before Exercise Had Increased Cardiac Output, Stroke Volume, and Peripheral Muscle Oxygenation – All Indicators of Improved Heart Function.
- The Refectchers Suggest that Ketones May Improve Heart Health But Emphasize That Research Is Ongoing.
Type 2 Diabetes, Which Is Affecting Increasing Numbers of People Worldwide, Occurs When the Body Stops Responding to Insulin, The Hormone That Controls Blood Glucose. When the insulin does not work correctly, Glucose Remains in the Blood InstaD of Being Take Cells to Be used as Energy.
If Blood Glucose Is Not Controlled, This Can Lead To Complications, Which May Include Cardiovascular Disease.
Treatments for type 2 diabetes aim to reduces Blood Glucose Levels. One Type-Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2I)-Also Appears to Protect the Heart, Possibly by Inducing Ketosis, A State Where The Body Uses Fats Institute of Carbohydrates as An Energy Source. The Liver Converts Fats into ketones, Which Cells Metabolize to Release Energy.
A Previous Study Found Thatone Supplements Reduced Postprandial Blood Glucose Concentrations in People With Type 2 Diabetes and Calleed for Research into other positive Benefits of the Treatment.
To testher ketosis is responsible for the Heart Benefits of Sglt2is, A Team From Portsmouth University in the United Kingdom Gaveone Ketone MonESesters (Exogenous Ketones) to a Group of People with Type 2 Diabetes and The Measured Their Their Function.
“People with Type 2 Diabetes Reported Find Physical Activity and Exercise Difficult. This is Baste their Heart Cannot Use Glucose, The Most Efficient Body Fuel, Due to Insulin Resistance. In The Current Study, The Hearts of All 13 of the participants were working more efficiently After The Ketone Drink at Rest and During moderate Intensity Exercise, Compared to the placebo Drink. HELE, to Ketone Drink has the potential to be an adjunct treatment to improve cardiac function and quality of life in People with Type 2 diabetes. However, Larger and Longer-Term Efficacy and Safety Trials Are Warrad. “
– Study Author, Dr. Maria Perissiou from the University of Portsmouth’s School of Psychology, Sport and Health Sciences.
The work is published in the Journal of Applied Physiology.
Cheng-Han Chen, MD, Board Certified Interventional Cardiologist and Medical Director of the Structural Heart Program at Memorialcare Saddleback Medical Center in Laguna Hills, CA, TOLD Medical News Today that This Study Forms A Basis For Further Research:
“This was A Vary Small Study (with 13 patients) that reported significant different in Heart Function and Muscle Oxygenation after Ketone Monoester Drink. “
OLDER ADULTS WITH TYPE 2 GIVEN KETONE DRINK DIABETES
Researchers Enrolled 13 People (Six Men and Seven Women) with a Mean Age of 66 Years in the trial. The participants had Mean Body Mass Index of 31.3, With Only 4 Having A BMI in the Healthy Range (Less Than 25). ALL HAD TYPE 2 Diabetes But No other meaning Health Conditions Related to It.
All participants attenthed to screening session for Blood tests, resting
AT EACH OF TWO EXPERIMENTAL VISITS, REACHERS GAVE THEM EITHER A KETONE MONESTER (0.3ML/KG), OR AN IDENTIAL PLACEBO DRINK. EACH participant had the ketone drink eleven and placebo eleven, but neither the refers
The participants have subd for 30 minute before undertaking a Step-Inmental Cycling Test. The Measured Heart Function Using Refers
Ketones Improve Heart Function
In all the participants, Heart Function Was Better After The Ketone Drink than Afterbo, Both When Resting and When Undertaking Moderate Exercise.
The Researchers Found Thating Ketone Treatment, Not only Did Circulating β-HydroxybutyRate (Which Carries Energy from the Liver to Cells) Increases but there was Also an increase in Both cardiac output and stroke volume.
Dr. Menka Gupta, Functional Medicine Doctor in Singapore, and Founder of Nutranourish, Explained Why The Treatment Might Have This Effect, Tellling MNT:
“Exogenous Ketones Offer A Highly Efficient Fuel Source for the Heart. They produces More ATP per molecule of oxygen than glycose metabolism and May reduces the production of reactive oxygen speries, Thereby Lowering oxidative stress and inflammation. By Reductive Oxidative Stress and Inflammation, They Could Help Protect Cardiac Tissue, Which Is particularly Important for Individuals with Metabolic Challenges. ”
Howles Help The Heart
“It is thought that ketones (Specifically Beta-HydroxybutyRate) Can Improve Cardiac Function by serving as a supplent energy source in addition to glucose and fatty acids. There is also thought they provides anti-inflammatory properties, as well as Improve Vascular Function. ”
-Cheng-Han Cen, MD
The Effects Were Seen With The Low Dose of Ketones Given to the Participants. Perissiou Explained Why they used this low dome:
“While Generally Consider Safe When Taken in Appropried Doses, Ketone Monesesters Can Pose Risks Including Potential Stomach Upset, Electrolyte Imbalances, particularly for People with Kidney Issues, and May Cause Cause Negative Effects Large Quantities Due to Their Ability to Signantly Raise Blood Ketone Levels. ”
Should I Take Ketone Supplements?
The Authors ACKNOWLEDGE That their Findings Apply Only to the Experimental Conditions of Their Study, So More Research is Needed To Ascertain Whether Ketone Supplementation Might Have Longer-Term Benefits for People With Type 2 Diabetes or Even for Thue with the condition.
Perissiou outlined The Next Steps in Their Research:
“We are Currently Exploring The Dose-Repare Relationship of a ketone drink and cardiovascular function in Healthy Individuals. In Addition, We Recently Acquired Further Funding to Explore The Physiological Mechanisms By Which Chronic Ketones Ingestion Can Mitigate The Cardiovascular Burden Impaed In People With Type 2 Diabetes During Heat Waves.
“Individuals with Type 2 Diabetes Present with Well-Document Metabolic Challenges, and Lower Oxidative Stress and Inflammation Benefits Their Condition. It is positive that similar benefits mights extend to thhue without the condition. That Said, People with Diabetes Could Experience More Pronounced Improvements Due To Their Issaired Metabolic Flexibility. FUTURE STUDIES INVOLVING NON-DIABETIC OR PRE-DIABETIC POPULATIONS WILL HELP CLARIFY WHOTHER THE BENEFITS OF EXOGENOUS KETONES ARE UNIVERSAL OR MORE CONDITION-SPECHIFIC. “
– Menka Gupta
