- Researchers at UVA Health Have Found That A Class of HIV Drugs Called Nucleotide Reveal Transcribed Inhibitors (Nrtis) May Signanantly Reduce The Risk of Developing Alzheimer’s Disease.
- Their Large-Scale Analysis of United States Health Insurance Data Reveared That Patients Taking in Sex Medications had up to 13% Lower Risk of Alzheimer’s Disease Each Year.
- Based on before Findings, The Team Is Calling for Clinical Trials to Test Whether these Drugs Could Be used to Help Prevent Alzheimer’s.
Scientists are calling for clinical trials to investigate whether a class of Hiv Drugs Known as nucleotide reverse transcriptase inhibitors (nrtis) could Help Prevent Alzheimer’s Disease.
In Their New Research, They Found That People Taking in Significantly Less Likely To Develop The Condition.
The Team Had Earlier Discovered to Possible Biological Mechanism Explaning How the Drugs Might Offer Protection Against Alzheimer’s.
The Findings were published in
Reded Risk by 6-13%
Alzheimer’s Disease Is The Leading Cause of Dementia, Responsible for Approximately
Motivated by This, The Researchers examined Two Major Us Health Insurance Databases and Found That the Risk of Developing Alzheimer’s Dropped by 6% Per Year in One Dataset and by 13% Per Year in The OTher Among Patients On Nrtis.
Jayakrishna Ambati, MD, Founding Director of Uva’s Center for Advanced Vision Science and A Professor in the Department of Ophthalmology at the University of Virginia School of Medicine, and Senior of the Study, Explained The Key Findings to Medical News Today:
“We analyzed Health Insurance Databases of Tens of Millions of People and Made the Surprising Discovery That People Taking A Group of Anti-Hiv Drugs Called Nrtis Had A ~ 10% Reduction In The Risk of Developing Alzheimer’s Disease for Every Drugs. “
– Jayakrishna Ambati, MD
Investigating the link Between nrtis and Alzheimer’s Risk
Nrtis are Commonly used to stop HIV from replicating in the body.
However, Jayakrishna Ambati and His Research Team Had Previous Found ThatSe Drugs Also Block The Activation of Inflammmasomes, Key Immune System Components that have been Linked to the Development of Alzheimer’s Disease.
This Discovery Led Them to Investigate Whether Patients Taking Nrtis, Which Also Treat Hepatitis B, Might have Lower Risk of Developing Alzheimer’s.
To explore this, The Team Analysed Long-Term Health Data From Two Major Us Sources: 24 Years of Records From The Veterans Health Administration, which predominantly includes mallents, and 14 years from the marketscan database, which covers a more diverse Population
They Focused on Individuals Ages 50 and Older Who Were Being Treated for HIV OR HEPATITIS B AND WHHO HAD NO PRIOR DIAGNOSIS OF ALZHEIMER’S.
The Refrachers Identified Over 270,000 Qualifying Patients and Asessed How Many Later Developed Alzheimer’s.
AFTER ACCOUNTING FOR POTENTIAL CONFUNDING FACTORS, Such As Existing Health Conditions, They Found That Thue Taking Nrtis Experienced Marked and Meaningfor Reduction In Alzheimer’s Risk.
Clinical Trials Needed to Assess Potential of Nrtis For Alzheimer’s
The Refers Observed The Reduced Risk of Alzheimer’s Was Specific to Patients Taking Nrtis and was note in Those using other Types of Hiv Medications.
This distinction led them to conclude that nrtis Should be formally tested in clinical trials to assses their potential to Prevent Alzheimer’s Disease. If from Effective, The Impact Coul Be substantial.
With Nearly 7 Million America Currently affected by Alzheimer’s and Projecting Indicating That Number Could Double To 13 Million By 2050, The Need for Preventive Treatments is Growing.
In Adionion, The Financial Burden is Experienced to Rise Sharply, With The Annual Cost of Care for Alzheimer’s and Related Dementias Projected to Increase From $ 384 Billion Today to Nearly $ 1 Trillion in The Coming Decades, According to The Alzheimer’s Association.
“It’s estimated that 10 million People Develop Alzheimer’s Disease Around the World Every Year. 10% Reduction in Risk could have a dramatic effect on the impact and burden of Alzheimer’s,” Dr Ambati Explained.
“There are sum ongoing clinical trials of nrtis in alzheimer’s dissearated Those Side Effects.
– Jayakrishna Ambati
How HIV Drugs May reduces Alzheimer’s Risk
James Giordano, PHD, Professor Emeritus of Neurology and Biochemistry, Georgetown University Medical Center, Washington, DC, Who Was Not Involved in the Research, Told MNT that “This is an interesting retrospective study.”
“It provides evidence that uses of nucleoside to reverse transcripta inhibitors (nrtis) that has been used to treat human immunodeficy virus (HIV), and which inhibit development of inflammmasomes, is positively correlated to a reduced Incident of Alzheimer’s Disease.”
“This is Noteworthy in that severe Lines of Converging Evidence Have Shown That Bodily and Cerebral Inflammatory States Can Induce Production of Both Tau and Amyloid Proteins in Brain That are contributory to the pathology of (Alzheimer’s),” Giordano Added.
“Inflammasomes are cellular proteins that Aggregate and form discrete structures Bown in responsibility to tau and amyloid agregation, as well as following certain viral and bacterial infections, trauma, alterations in immune function, and exhibition to varying stressFul Environmental Factor Factors.”
“James Giordano, PhD.”
“Inflammasomes induce changes in mithochondrial function, cell metabolism, calcium regulation, can contribute to the formation of neural plates and tangles, and can induce Form of Cell Death, which has been implied in the genesis of Alzheimer’s,” Giordano Explained.
Inflammation, nrtis, and Alzheimer’s
“This Study Strengthens The Hypothesis that inflammmasome -mediated inflammatory processes are operational in alzheimer’s and offers potential direction for the development of nrti type drarugs and molecular agents aimed at mitigating inflammmasome development as a viable treatment-or perhaps-or perhaps Preventive Intervention – For Alzheimer’s. ”
“James Giordano, PhD.”
