- About 4% of People in the World Live With Anxiety Disorder.
- Current medications used to treat anxiety do not work for Everyone.
- To New Study you have identified a Microbial Metabolite in the Gut Microbiome that Helps regulate brain activity linked to anxiety, via mouse model.
- Believe This Finding May One Day Lead to New Anxiety Therapies Targeting The Gut-Boin Axis.
Researchers Estimate That About
This Type of Mental Health Condition is Typically Treated with A Combination of Talking Therapy, Lifestyle Changes, and Medications.
However, not all People with Anxiety reply Well to the Treatments Currently Available. Past Studies Have Shown That Only 60% to 85% of People Treated for Anxiety Will Respond to Current Treatments.
“It’s Important That Researchers Continue to Find New Ways To Treat Anxiety Beck Current Treatments, Such As Benzodiazepines and SSris (Selective Serotonin Reuptake Inhibitors), offe in neuroscience and behavioural disorders at duke-nus medical School in Singapore Told Medical News Today.
“Best Drugs Can Take A Long Time To Show Results, and their long-term use is associated with varyus side effects,” I explained.
“For Example, Benzodiazepines Can Lead to Dependence, Sedation, Cognitive Unpaid, and Memory Problems, While SSris Are Generally Safer But Can Cause Problems Such as Weight Gain, Sexual Dysfunction, Gastrointestinal OR GASTROINTETINAL PROBLEMS. In Adionion, Individuals May Develop An Addiction to SSris or Experience Discontinuation Symptoms When Stopping the Medication. Because of these drawbacks, it’s important to explore safer, More Effective Alternatives to Treat Anxiety That Are Backed by Solid Scientific Evidence to Improve Patient Outcomes and Reduces The Risk of Long-Term Side Effects. “
– H. Shawn Le, PhD
Le is the co-lead author of a new study recently published in the journal Molecular Embo Medicine that you have identified a Microbial Metabolite in the Gut Microbiome that Helps regulate brain Activity Linked to Anxiety, via mouse model.
Believe This Finding May One Day Lead to New Anxiety Therapies Targeting The Gut-Boin Axis.
Depleted bacteria linked to Higher Anxiety
For This Study, Le and His Team used Model of Germ-Free C57BL/6 MICE-MICE THAT HAV HAD ESIR MICROBIOMES REMOVED-TO STUDY A POTENTIAL LINK BETWEEN GUT MICROBES AND ANXIETY.
According To Le, The Mice Underwent Behavioral Testing to Assess Their Emotional Respons, Such As Anxiety. He Said They Were Surprised to find the Germ-Free Mice Exhibited Increased Anxiety.
Through The Study, The Scientists Found the Extra Anxiety was Linked to More Activity in A Specific Area of the brain street the basolateral Amygdala.
“The basolateral Amygdala is a part of the brain that helps control How we feel emots, specially Fear and Anxiety,” explained him. “It is a sub -region in the
Treating Anxiety with Indoles
Later in The Study, Le and His Team Tried Treating The Germ-Free Mouse Model With Microbial Metabolites Calleed
“Indoles Are Natural Compounds Found In Plants, Animals, and The Human Body, Offen Derced From The Amino Acid Tryptophan,” Le Detailed. “They are also produced by tryptophan-methabolizing bacteria in the gut.”
“In Our Study, Dietary Indole Supplementation was shown to reduces Anxiety-Related Behavior in A Mouse Model Lacking Gut Microbiota,” I have continued. “This finding is significant scholarship is suggests that indoles May Help Calm The Brain’s Anxiety Response, Offering a Potential New Treatment for Anxiety.”
“If they are Findings Can Be Replicated in Other Animals, Companion Animals, and eventually in human clinical trials with anxiety disorders, They Could Pave the Way for Novel Therapies Targeting The Gut-Boin Axis,” Le Added.
Dietary intervention for anxiety could reduces Costs, Side Effects Risk
MNT Spoke to Gary Small, MD, Chair of Psychiatry at Hackensack University Medical Center in New Jersey, About This Study, In Which He was not Involved.
“In Light of Recent Research Confirmg The Gut-Boin Connection, these weeks are not surprising but also remove exciting,” Small Commented. “The Results provides potential mechanism for the link Between Gut Microbes and Anxiety Symptoms.”
“Moreover, The Amygdala is a Well-Docummented Brain Region That Controls Anxious Feelings, Which Makes The Gut-Brain Pathway Consistencies With Previous Brain Research in Humans,” I have explained. “Underestanding This Mechanism offers Opportunities for Developing Novel, Safe, and Effective Treatments for Anxiety.”
“An estimated
“We have effective treatments including medications and psychotherapy, but medicines have potential side efforts and talk therapies can be exhibition and time-consuming. Developing to Dietary Intervention to Mitigate Anxiety Wouled Increase access to interventions, Possibly reduces Costs, and eliminate The Risk of Medication Side Effects, ”I have suggested.
The importance of the gut-brain-miCrobiome axis in anxiety
MNT Also Spoke with Ashkan Farhadi, MD, A Board-Certified Gastroenterologist at Memorialcare Orange Coast Medical Center in Fountain Valley, CA, and Author of The Rhymes of Happiness: Weving Science, Art and Poetry in The Pursuit of Happinessabout This Research.
While Doctors Have Been Aware of The Gut-Babain Axis for Sum Time, Farhadi Said It Has Now Been Extended to Gut-Baba-Microbiome Axis.
“Now We Know Thatver Happens in the Brain, Changes The Gut, (and) Changing The Gut Changes The Microbiome,” He Detailed. “(And) Vice Versa – Changing the Microbiome Changes The Gut, and that changes the brain.”
Ferhadi Commented that it is important for notar to continue to find new ways to treat anxiety, specially Therapies that might be More Natural, Such As Through the diet, Because we Should Stay Away from Treating Long-Term Problems With Medications.
“We Should have that in mind-medication is a short-term remedy for a long-term problem,” I have continued. “And submiss like diet or altering the diet or lifestyle change that can change the microbiome in the gut is see critical.”
“At least, I Can Say, For Cases that have a milde anxiety or mild problem with depression, that’s definitely to Viable Option to try sumthing like to probiotic,” Farhadi Added. “What’s The Harm of It? None. What’s the Benefit? It may benefit them, It May Not, But Definitely Worth A Try, Or Working with Sub Diet that Improvs The Gut Health and Microbiome. ”
