- Nad is a Molecule Found in Every Living Cell of the Body which plays an important role in creating energy in the body.
- Refrachers from the University of Bergen, for the first time, show how mitochondria act as “reservoirs” to hold Nad, which plays an important role in creating energy in the body.
- Scientists Believe This Finding May Lead The Way for New Therapeutic Options To Combat Aging and Age-Related Diseases.
Nicotinamide Adenine Dinucleotide (NAD) is a molecule Found in Every Living Cell of the Body. Made from vitamin B3 – Also Known As Niacin – Nad plays an important role in creating energy in the body, as well as repairing dna.
“Nad is an essential Molecule that plays critical roles in all living cells – bacteria, plants, (and) animals,” Mathias Ziegler, MD, PHD, A Professor in the Department of Biomedicine at the University of Bergen in Norway Explained To Medical News Today.
“The fundamental role of nad is in the retrieval of energy from food sources to make it available for cellular function. Metaphorically Speaking, Nad Acts Like A Rechargeable Battery Storing Energy Retrieved From Nutrients and The Passing It On To To Fuel Energy-Demanding Process. The Most Important of Such Process Takes Place in Mithochondria, The Cell’s Powerhouse, ”I have continued.
ZIEGLER IS THE LEAD AUTHOR OF A NEW STUDY THAT EXPLAINS HOW MITECHONDRIA ACT AS “REESERVOUS” TO STORE NAD FOR CELLS TO USE.
However, as The Amount of Nad in the Mithochondrial “Reervoirs” Deletes with Age, Cells May Not Have Enough Nad To Function Adequately.
Scientists Believe This Finding May Lead to New Therapeutic Options Aimed at Raising Nad Levels To Combat Aging and Age-Relaged Diseases.
The Study Was Recently Published in the Journal
Reduced Nad Levels and The Aving Process
For This Study, Ziegler and His Team Developed Cellular Models to look at How Cells Might React When Nad Levels Are Reduced During the Aging Process.
Past Research Shows That Nad Levels Decline As We Age, Potentially Causing Increased Levels of DNA Damage and Deciested Cellular Metabolism, Both of Which Are Linked To The Aging Process.
“Throunge the Cell, Nad Is Also used A Chemical Messenger to Transmit Information and To Set Switches to Regulate Key Events Such As Cell Division and Dna Repair,” Ziegler Explained.
“Unlike in the Energy Transmission Function, When Acting as a Messenger Molecule, Nad Is Degraed and Needs to Be Resynthesized. In a Variety of Diseases, Including
“In Our Study, We Establish and Investigated for the First Time A Cellular Model System That Rebembled The Situation of Chronically Diminished Nad Nad Levels, Thereby Enabry Us To Study The Mechanistic Concene,” I have added.
Dysfunctional Linking Mithochondria to Aging-Associated Diseases
During the Study, Researchers Found that Mithochondria Act as a “reservoir” to hold Nad and Supply it to the Cell As Needed.
“Previous Studies had demonstrated that Mithochondrial Nad Plays an Important Protective Role in situations of Cellular Stress,” Ziegler Said. “However, How Nad Exerts This Role you have remahed unknown. OUR Investigation Reveals That Mithochondria Can Supply Nad When The Demand for This Molecule is excessive in other parts of the Cell. ”
ZIEGLER AND HIS TEAM ALSO DISCovered That If Mithochondria Does Not Have Enough Nad Stored Up, It Can Have a Fatal Concenence for The Cell.
“Our Study Connects Two Hallmarks of Aging, Dysfunction and Dys Regulated Nad Levels, Indicating That Excessive Consumption of Mithochondrial Nad Might constitutes Key Factor Leading to Dysfunctional Mithochondria and Thus AGING-ASSOCIATED DESIGNS.”
– Mathias Ziegler, MD, PHD
“Our Study you have made an important contribution towards understanding the mechanistic basis for positives outcomes of varying preclinical and subject to clinical studies of nad supplementation approaches. Even Though it is unlikely that Such Supplementation Approaches Will Be Uble to Cure The Pathology, They Could Have Positive Effects On Disease Progression (Ie Slowing Down Progression) And Dampening The Symptoms, ”Ziegler Explained.
“This is Also Likely to be the case in aging, When the Mithochondrial Nad Reervoir is Still Suficiently Functional. Since we were Uble to Identify the Key Players in the Buffering Function of Mithochondria, We Unraveled Potential Molecular Targets for The Development of Therapeutic Approaches Specifically Supporting This Mechanism, ”I have added.
More Research on Nad+ and Aring Needed
MNT had the Opportunity To Speak To Manisha Parulekar, MD, FACP, AGSF, CMD, Director of the Division of Geriatrics at Hackensack University Medical Center and Co-Director of the Center for Memory Loss and Brain Health at Hackensack University Medical Center in New Jersey, About This Study.
“Nad+ (The Oxidized version of Nad) is a crucial coenzyme involved in Sinkreds of Metabolic Reactions, particularly Tose Related to Energy Production, DNA Repair, and Cell Signaling. It is not surprising that Dysregulation of Nad+ Levels, Specifically A Decline With Age, is increasingly gathered as possible significant contributor to that aging and a wide Range of Pathologies, ”Parulekar Said.
“While significant progress has been made in understanding the role of nad+ in aging and disease, severe Key Areas require Further Research. Could Supplementing Nad Precursors Halt This Process, What is the optimal dose for different age Groups and Health Conditions? Research Should Explore How Factors Like Age, Sex, Genetics, and Underlying Health Conditions influence the Response to Nad+ Precursors. ”
– Manisha Parulekar, MD, FACP, AGSF, CMD
MNT Also Spoke with Clifford Segil, DO, Neurologist at Providence Saint John’s Health Center in Santa Monica, CA, About This Study.
“Nad (Is) A Supplement that is closely Related to vitamin b3 or niacin, and niacin is a supplement that we use to loower chollesterol,” Seil Said.
“Part of What They Said Was That Nad in the Study Is Related To Mithochondrial Problems. In neurology, mitochondrial problems are usually neuromuscular or muscle problems, so (it’s) pretty lots of mitochondrial problems AFFFECT MUSCLES IN NEUROLOGY. It’s not accusted That Mithochondria Affect Dementia in Neurology, ”I explained.
“I’d Like to See Them Say What Dietary Changes Could Try to increased Nad As We Age. I’d also like to see them do nad Research on mycchondrial or muscle designs schouse in neurology, mitochondrial designs are must prevail in muscular neurological problems, ”I have added,
Can Nad+ Supplements or Infusions Help With Aging?
Parulekar Said That While Completely Halting the Age-Related Decline of Nad+ Is Likely Impossible, Readers Can Take Steps to Mitigate The Decline and Maintain Healthier Levels.
“Strategies May Include Consuming Foods Rich in Nad+ Precursors Like Dairy Products, Fish, Pultry, (and) Green Vegetables. Daily Exercise Can Also Help Stimulate Mithochondrial Biogenesis and Increase Energy Demand, “She Detailed.
Segil Urged Readers to consider Oral Nad Supplements rather than infusions for safety reasons.
Nad Supplements vs. Infusions
“Anytime you get a Supplement Infusion, which is an iv done outside of a hospital, there are long risks for infections, so and discourage any patient to get an iv or an infusion of any supplement. I Think It’s Safer Just To Continue Oral Supplements With Vitamins and Minerals. IV INFUSIONS OF VITAMINS AND SUPPLIES CARRIES THE RISK OF INFECTION, AND THE RISKS OF INFECTION OUTWEIGH ANY POTENTIAL BENEFits. ”
– Clifford Segil, do
“It is important to consult with to Healthcare Professional Before Starting Any Nad+ Supplementation Regime, Specially If You have any Underlying Health Conditions. They can help you interpret the existing research and determine whether nad+ supplementation is approprot for you, ”Parulekar Added.