- The Link Between diet and depression is a Critical Area of Research. It could lead to finding effective strategies to treat depression.
- A Study Found That Mice Who consumed A High-School Diet Developed Depression. The Findings Also Sug forest that This was the High Salt Diets Affected the Production of the Cytokine Il-17A.
- The Results Highlight Another Potential Reason to Limit Salt Consumption.
The World Health Organization (WHO) Estimates That
Experts Want to Find Effective Treatment Strategies, and One of Focus is diet, with evidence suggesting that following to Healthy Diet and Avoiding Components componts Like Junk Food May Help Decree Depression Risk.
A Study Recently Published in The Journal of Immunology Looked at The Relationship Between Consumption A High-School diet and depression-like symptoms in mice.
They Found that Mice Who Receive A High Salt Diet Developed Depression-Like Symptoms and That This was Likely Related to the induced production of the cytokine IL-17A.
The Results Open The Door for Future Research into depression and possible treatment.
How are high-to diets and depression linked?
SOUGHT TO EXPLORE HIGH SALT CONSUMPTED DEPRESSION IN MICE REVERSE. First, They Tested if Mice Who Received High Salt Diet Developed Depression.
MICE HAD EUTER A NORMAL OR A HIGH-SALT DIET FOR 5 TO 8 WEEKS. Researchers used Few Methods to look at mice’s behavior. They Also had positive control of Mice that were exhibited to chronic restraint, which is “a common depression-like model.”
The Mice on the High-Salk Diet Displayed Behaviors Similar To Those of The Positive Control Mice. This indicates that the high salt-diet caused the mice to exhibit depression-like behavior.
They also found that also mice experienced an increase in
Their Analysis Reveared That Certain Cells Produced More IL-17A, and They Also Found Increased Levels of IL-17A in Mice’s Spleens and Areas of the Brain. This suggests that the high Salt Diets Promoted the Production of this Critical Cytokine.
To Further Investigate This, Researchers used mice with a rorγt deficiety. They Note That This Transcriptional Factor Is Sub Subject is needed for il-17a to be produced.
They Fed Tohese Mice The High-School Diet and The Saw If They Developed Depressive Symptoms. These Mice Demonstated Much More Normal Behavior Than Those with the transcriptional factor. These Mice Also Did Not Experience Increased Levels of IL-17A.
The Authors Note That Their Findings “Suggest that (A High-Salle Diet) Drives Depression-Like Behavior in Mice Through inducing IL-17A PRODUCTION.”
The Refectchers Note that Several Lymphocyte Population Can Produce IL-17A, So They Next Tried to Determine The Distribution of Cells That Make IL-17A IN THE MICE’S BRAINS, PERIPHEAL BLOOD, AND SPLEENS.
They Found That γδt Cells Were Likely A Major Cell Source of the Increased Levels of Il-17a in the Mice That Receive The High-Salth Diets.
The Results Also Indicated That Mice On The High Salt Diets Experience An Increase in γδt17 Cells. Refrachers Note Further that the γδt17 Cells were a Critical Source of IL-17A in the Mice Who Received The High-School Diet.
Finally, Researchers Wanted to see if the production of IL-17A by the γδt Cells contributed to the depression behavior of the Mice Who Received the high-Salk diet. To do This, they used an anti-γδtcr antibody to diminish the γδt cells. They Found That After This, The Depression-Like Behavior in high-Salk diet Mice Diminished.
The Authors Note That “(c) Olectively, Our Findings Show That (A High-School diet) DRIVES DEPRESSION-Like Behavior in Mice at Least Partially Through the Induction of γδt17 Cells.”
The Results Uncover Critical Information about How Salt Intake Coul Impact Depression.
Richard C. Calderone, Do, MPH, FAAP, FACP, AN OSTEPHIC PHYSICIAN SPECIALIZING IN INTERNAL MEDICINE, WHO WAS NOT INVOLVED IN THIS STUDY, NOTED TO Medical News Today That:
“Although before Findings were in mice, it is reasonable to investigate the Effect of Limiting Salt INTAKE ON DEPRESSION IN HUMANS. It Should Be notted that depression is a complex, multi-Factorial Condition, and That Even With Promising Studies like This The Quantity of Salt INTAKE NEEDING TO DEMONSTRATE ANY CLINICAL DIFFERENCE IN HUMANS A Biological Explanation for the Association Between High Salt INTAKE AND DEPRESSION, Identifying New Targets for Potential Treatments. ”
Do tobe Research Findings Apply to People?
This Research Used Mice, offers Critical Data Collection Component That Provides Useful Information. However, More Research Will Likely Be Needed To Confirm What This Study Found.
Robert Hostoffer, DO, An American Osteopathic Association Board Member, Not Involved in the Study, Told MNT That, “In general, it is difficult to interpret Data from Mouse Studies Due to Their Difference in Nomenclature of Their Immune Systems, Both Soluble and Nonsoluble Components.”
“CAUTION SHOULD BE EMPLOYED WITH THE DATA IN REFERENCE TO HUMAN SUBJECTS. ALSO, THE DETERMINATION OF DEPRESSION IN MICE IS DIFFICULT TO TRANSLATE TO DEPRESSION IN HUMANS,” HOSTOFFER ADVISED.
More Research Would Be Required to see if People Would Experience similar results and what the long-term Effects might be. Additionionally, More Research to Confirm The Findings On The γδt Cells May Also Be Helpful.
The Study Authors Note That Examination of the Molecular Mechanisms Involved in “HSD-Induced IL-17A PRODUCTION IN γδt Cells” Will Also Be Helpful in Future Research.
The Refrachers Did ACKNOWLEDGE THAT HIGH-SALT DETATS MIGHT AFFECT DEPRESSION SOMETHAT DIFFERENTLY BAKE OF THE BEHAVIOR THES OBSERVED IN MICE WHEN THE HIGH-SALT DIET AND CHRONIC RESTRAINT STRESS COMPONTS WERE COMBINED.
It was different Than when the mice only experienced the depressive behavior Broucht on by chronic restraint stress. They noted that “This suggests that there might be alternate efforts of hsd or the combined treatment on depression-like behavior.”
How to Minimize Salt Consumption
This Study Emphasizes Another Potential Reason Why Minimizing Salt Inntake Is a Good Thing, As It Court Offer Benefits for Mental Health in Addition to the Note The Physical Health Benefits.
As noted by the
Registered Dieitian Nutritionist Karen Z. Berg, MS, RD, CSO, CDN, Not Involved in the Recent Study, Explained To MNT That: “High sodium intake is specially bad for your heart and kidneys. People Who has heart disease, Kidney Disease, Diabetes, Or Fatty Liver Need to Really Watch their Sodium Intake So That They Don’t Make Their Conditions Worse.”
Berg Further Note The importance of seeing sodium consumption in a Realistic Way Because Amounts Can Often Get Confusing:
“The dietary Guidelines for Americaons recommends that healthy adults limit their sodium to 2,300 mg (millioniRRAMS) per day. That May Sound Like A Lot, But it’s the equivalent of advout 1 teaspoon of salt! In Order for an item to be classified as ‘Low-Sodium,’ It has to have 140 mg of sodium or less per serving.
