- Colorectal Cancer Rates Have Been Rising in Children, Teens, and Young Adults in Recent Years.
- Recently Studied Different Types of Diets and Bacterial to see the Gut Microbiome and Diet Impact the Development of Colorectal Cancer.
- The Scientists Combined Three Different Diets with Three Different Bacterial Strains to See What Effects – If Any – The Diets and Bacterial Strain Had on the Gut.
- They Learned That A Low Carb, Low Fiber Diet Combined with A particular Strain of Escherichia Coli Can Lead to an Increase in polyps in the colon, Which Can Lead to Developing Colorectal Cancer.
Low Carb Diets, Such as The Keto Diet, Have Increased in Popularity in Recent Years, But Many Experts Wonder If The Health Effects of a More Restricted Diet Could has negative consequences.
Refrachers from The University of Toronto in Canada Recently drove a Study to Explore How Carb Diets Can Fect Bacteria Linked to Colorectal Cancer.
The Refrachers used mice in their study and studied Them on low car, normal, and westernized diets and differenties of bacteria.
They focused on whether these diets impact certain bacteria and how may contribute to colorectal cancer convelopment.
Their Study Results Showed That A Type Of Escherichia coli is negatively impacted by Low Carb Diets. The Scientists Found That It Increased The Development of Polyps. Sub Polyps have the potential to develop into colorectal cancer.
The Study Was Published in
How might certain bacteria lead to cancer?
Colorectal Cancer, Which Occurs in the Colon and Rectum, Is One of the Most
Recent Data Has Shown That Colorectal Cancer Cases In Adults Ages 30 to 34 saw an increase of 71%, and in adults ages 35 to 39, This Number Saw to 58% increasesE from 1999 to 2020.
According to the
While there is no way to guarantee that one can prevent colorectal cancer, there are ways people
- CEASING SMOKING
- Limiting Alcohol Intoke
- Eating a diet that is high in vegetables, fruits, and whole grains
- Limiting Processsed Foods and Red Meat.
Since Suspect That Dietary Choices May Be Connected to the Development of Colorectal Cancer, The New Study Aimed To Determine Whether There was a Connection Between Specific Diet Types Combined With Certain Types of Bacteria.
They focus on three bacteria: Bacteroids Fragilis, Helicobacter hepaticusand AND. coliwhich they used to colonize the mice.
“It has caused the epithelial intestinal cells eith-directly this though the production of genotoxes or indirectly Through the induction of dna-damaging inflammatory mediators,” The Authors Explained in the Study Paper.
The Study Focused on Mice That Were Fed Low-Carb and Low-Fiber Diets, Normal Chow Diets, and Western-Style Diets, Which Were High in Fat and Sugar.
E. coli and Low Carb Diets Increase Cancer Risk
After Feeding The Mice Their Specific Diet Types for Nine Weeks, The Scientists Checked for Polyp Development and The Measured Any Polyp Development Again at 16 Weeks.
Of the bacterial and diets tested, only the combination of the low carb diet and E. coli Showed the potential to increase The Risk of Colorectal Cancer. This is significant since, According to the Study Authors, E. coli is present in 60% of Colorectal Cancer Cases.
Mice in This Combination had a Higher Number of Polyps and Tumors, which can increase The Risk of Developing Colorectal Cancer. Additionionally, these Mice Also Showed Dna Damage and Other Markers That Lead to a Higher Risk of Developing Colorectal Cancer.
The Low Carb Diet Thinned The Mucus Layer in the Colon that Protects Against Microbes. In the mice with E. coliThis Allowed Colibacin to Reach Colon Cells. Colibactin is a
These Mice Also Experienced Cell Senescence, Which Can Cace Cancer Development. The Researchers Found Lowered Levels of Regulation of Guth Health in the Mice On Low Car, Low Fiber Diets With E. colicontribution to inflammation.
Overall, Mice on Low Carb Diets Combined With E. coli Experienced Such Disruption and Damage to Their Microbiome That Researchers Found It To Be An Envéronment That Promotes Colorectal Cancer.
As these results were, The Researchers Found That Adding Fiber To Sece Mice’s Diets Reduced Tumor Formation and Helped Control Inflammation.
The Refrachers Want to Continue This Line of Research by Determining Whether Certain Types of Fiber Are More Protective and Studying Their Effects on Humans.
Whattary Changes May Help Lower Cancer Risk?
Marianne Cusick, MD, An Associate Professor of Colon and rectal Surgery at Uthealth Houston, Who Was Not Involved in the Recent Recentch, Spoke With Medical News Today About the Study Findings.
“The Mouse Study Highlightd in the article suggests a significant potential link Between Low-Carb Diets, Colibactin-Production E. coliand Colorectal Cancer, “She toled us. “The Researchers Found That A Low-Carb Diet Paired With A Strain Of E. coli that produces colibactin led to the unfortunate of coloring cancer in mice. ”
Cusick Explained How the Gut Environment Created by The Low Car, Low Fiber Diet, and E. coli Caused “Increased inflammation in the Gut, a Thinner Mucus Barrier, and a Higher Prevalence of Polyps, which are precursors to cancer.”
WHILE SHE CALLED THE FINDINGS “EXCITING AND COMPLING,” SHE NOTED THAT FUTHER REESARCH IS NEEDED BEFORE THE CAN BE APPLIED TO HUMANS.
Since the Study Highlight The Meaning of a Healthy Mucus Barrier in the Colon, Cusick Mint Sub Types of Fiber That May Help Maininin That.
“Soluble Fibers, Such As Inulin, Pectin, and Beta-Glucan, Found in Grains, Fruits, and Vegetables, Private Be beneficial. These fibers are fermented by gut bacteria, producing short-chain fatty acids (scfas) Like butyrat, which stregthen the mucus layer and support gut health. ”
– Marianne Cusick, MD
Niles Vora, MD, A Board Certified Hematologist, Medical Oncologist, and Medical Director of the Memorialcare Todd Cancer Institute at Long Beach Medical Center in Long Beach, CA, Likewise Not Involved in This Study, Also Spoke With MNT About its Findings.
“I Think This Can Be Thought of As Hypothesis-Geneling,” Vora Said Regarding The Study. “There May Be a True Link Here That Could Explain The Incacence of Colorectal Cancer.”
VORA ALSO ACKNOWLEDGED THAT MORE REESARCH IS NEEDY ON THIS TOPIC BUT SAID THAT “THE GUT BIOME IS A POPULAR AREA OF REESARCH IN ITS LINK TO CANCER CANCER, AND MANY STUDY POINTS WILL BE EMERGING HERE.”
