• People with Diabetes Can Also Have The Potentially Blinding Vision Condition Diabetic Retinopathy.
  • There Is Currently no cure for diabetic retinopathy.
  • A New Study Has Found That Semaglutide-The Active Ingredient Found in Sum LPG-1 Medications prescribed for diabetes and to aid weight loss-May Help Protect the Eyes from Diabetic Retinopathy.

According to the International Diabetes Federation, About 11% of the World’s Population Lives With Diabetes, With 90% Having Type 2 Diabetes.

Researchers estimate so much as 40% of All People with Diabetes Also Have Diabetic Retinopathy – A Potentially Blinding Eye Condition caused by Blood Vessel Damage in the Eye’s Retina.

There Is Currently no cure for diabetic retinopathy. The Condition Is Often Managed Through Injection of Anti-VEGF Medications into the Eye, Surgery, and Blood Sugar Monitoring and Control.

PAST STUDIES ALSO SHOW THAT ANTI-VEGF INJECTIONS MAY HELP PREVENT DIABETIC RETINOPATHY AND ITS COMPLICATIONS, AS well as healthy LIFESTYLE FACTORS LIKEGING BLOOD PRESSURE, LOWERING CHOLESTEROL LEVELS, MAINTAINING A HEALTHY WEIGHT, EATING A HEALTHY Not Smoking.

Now, New Study Recently Published in the Journal Pharmaceutics You have found that semaglutide – The Active Ingredient Found in LPG-1 medications Like Ozempic for The Treatment of Type 2 Diabetes and Wegovy for Weight Loss – May Help Protect the Eyes From Diabetic Retinopathy.

SEMAGLUTIDE DESARES Cell Death, Free Radicals in Eye Cells

For This Lab-Based Study, Researchers used samples of Human Retinal Endothelial Cells that were treated with different concentrations of semaglutide. The Cells Were The placed in a solution with Bh A High Glucose Level and High Level of Oxidative Stress – where there is an imbalance of antioxidants and free radicals – for 24 hours.

Past Studies Show That Oxidative Stress Plays A Role in The Formation of Diabetic Retinopathy.

At the Study’s Conclusion, Researchers Found That the Retinal Cells Treated With Semaglutide Were Twice as Likely to Survive The Cells That Were Untreated. Additionionally, The Treated Cells Were Found to Have Larger Stores of Energy.

Scientists Also Found That Three Markers of Diabetic Retinopathy Were DecueSed in the Semaglutide-Treated Retinal Cells. First, The Levels of apoptosis-A Form of Cell Death-DecueSed From About 50% in Untread Cells to About 10% in Semaglutide-Treatized Cells. The Production of the Free Radical Mithochondrial Superoxide DecueSed From About 90% to About 10% in the Treated Retinal Cells.

Researchers Also Found The Amount of Advanced Glycation End-Products-Harmful Compounds that can collect in People with Diabetes and Are Known to cause oxidative stress-Also Substantially decreases.

Lastly, scientists reported that the genes involved in the production of antioxidants were More Active in the Semaglutide-Treated Cells When Comparted To Untreated Cells. Believe This is a sign that Semaglutide May Help Repair Damage to the Retinal Cells.

“Our Study Did Not Find That Best Drugs Harmed The Retinal Cells in Any Way-Instead, It Suggests That Glp1-Rector Agonists Protect Against Diabetic Retinopathy, particularly in the Early Stages,” Ioanna Anastasiou, PhD, Molecular Biologist and Post Docc The National and Kapodistrian University in Grece, and Lead Author of this Study, Said in a Press Relay.

“Excitingly, before Drugs May Be Uble to Repair Damage That Has Already Been Done and So Improve. Condition. “
– Ioanna Anastasiou, PHD

SEMAGLUTIDE MAY HELP WITH OTHER EYE CONDIONS

Medical News Today Spoke with Benjamin Bert, MD, A Board Certified Ophthalmologist at Memorialcare Orange Coast Medical Center in Fountain Valley, CA, About This Study.

“We’ve known with any of these medications that are uble to reduce the Blood Glucose Levels in Diabetic Patients, Have Been Shown to Be Be beneficial long -term for the health of the microvascure that that exists in the eye,” Bert Said.

“What was unique about This Study is that it was showing that maybe with the semaglutide-Type Medications that it May Help to Protect from Oxidative Stress. And So This Could Potentially Be a Different Mechanism that it’s. to fascinating hypothesis and finding of this particular study. ”
– Benjamin Bert, MD

IF Semaglutide Can Help Protect Against Oxidative Stress, Bert Said It May Even Beable To Help With Other Eye Conditions.

“To Lot of The Damage That Happens To Our Bodies Is From The Oxidative Stress and Free Oxygen Radicals,” I explained. “We’ve Been Hearing for Many Years About Antioxidants and How Important Antioxidants Are To The Continued Health of Our Bodies, and All The Different Molecules, Minerals And Vitamins, and Things That You Can Take Hat Help As Antioxidants.”

“So If the LPG-1 Medications Also Have This Type of Impact On Our Cellular Function, The That Would Be Another Great Way To Be Uble to reduce this particular potentially Damaging Process,” Bert Added.

How does it compare to other retinal Therapies?

MNT Also Spoke With Jonathan Gloth, MD, A Board Certified Ophthalmologist and Retina Specialist, Hackensack Meridian Jersey Shore University Medical Center and Ocean University Medical Center in New Jersey, About This Research.

“I have reduced Diabetic Retinopathy in Patients on LPG-1 recipient agonists; therefore, The Study Results Were Consistency with What We’ve Been Seeing Clinically In Our Diabetic Patients,” Gloth Commented. “It is imperative that glp-1 medications are rigorously studied as they are commonly prescribed and their usage you have increased exponentially over the past few years.”

“I Would Like to see retina-specific Studies That Compare the Response to Our Current Retinal Therapies-Eye Infections, Laser Procers, and Surgery-In Those Patients on LPG-1 Receiver Agonists vs Those Who Are Not,” He Added.