• ATTENTION DEFICIT HYPERActivity Disorder (ADHD) IS MOST COMMONLY DIAGNOSED IN CHILDHOOD, BUT DIAGNOSES IN ADULS ARE INCREASING.
  • Adult adhd is Associated with a Higher Risk of Developing Dementia, But Experts Do Not Yet Know Why.
  • A New Study Has Found That People withd in Adulthood Have Increased Iron In Regions of Their Brain and Elevated Levels of Markers of Nerve Damage, Both of Which Are Also Seen In Dementia.

Research suggests that adults with adhd have a Higher Risk of Developing Dementia, and The Reasons for This Are Currently Unclear. Now, a New Study you have supporthed this link and suggesta the neurological mechanisms involved in This Increased Risk.

Professor Paul G. Unschuld, Head of the Division of Geriatric Psychiatry of the Hug, Associate Professor in the Department of Psychiatry at The Unige Faculty of Medicine, and The Initiator of the Study, explained in a Press Relay Why They The Carried Out The Research:

“Recent Epidemiological Studies Show That Adults Suffering From Adhd have an increased risk of dementia at an advanced age, but the mechanism through which adhd constitutes risk is not know.”

Their Study, published inPsychiatry and Clinical NeurosciencesFound that adults with adhd have increased lessons of iron in areas of the brain that are associated with cognitive function. They Also Found Blood Biomarkers of Nerve Damage, similar to thhue be in People with Dementia.

“The Findings provides an interesting perspective on the long-term neurological effects of adhd, but the study’s small sample size (32 adhd patients) Means Broader Conclusions Should DAMAGE Directly Increased Dementia Risk or if other factor (EG, Lifestyle, Medication, Genetics) Contribute to the observant Patterns. “

– Steve Allder, MD, Consultant Neurologist at Re: Cognition Health, Who Was Not Involved in the Study

Examination Iron Buildup in the Brain

Although Iron Plays An Essential Role in Brain Functioning, Excessive Accumulation Can Cause Damage to Nerve Cells and Immune Cells in The Brain, Leading to Neurodegenerative Diseases Such As Alzheimer’s. Studies Have Shown That As We Age, Iron Accumulates in Our Brains, and This May Be Associated With Poorer Cognitive Performance.

For This Study, The Recruited 32 Adults with A Clinical Diagnosis of Adhd (AGED 20-58 Years, Mean Age 35) and 29 Age-Matched Controls (AGED 19-59 Years, Mean Age 32). All participants Underwent Brain Magnetic Resonance Imaging (MRI), Standardized Psychometric Testing and Assume of Lifestyle Factors, Such as Smoking and Body Mass Index (BMI), That Might Affect the Health of Blood Vessels in the Brain, Potentially Increasing Dementia Risk.

To assess iron deposition in the brain, The Recemptive Susceptibility Mapping (QSM), A form of scanning that can detect areas of magnetism in the brain.

Marissa Sobolewski, PHD, Assistant Professor of Environmental Medicine and Neuroscience, University of Rochester Medical Center, explained the importance of this:

“Faith (Iron) is critically important for neuronal myellation and more research is needed to understand How Iron Overload can an important area for future research focused on neurodevelopmental disorders Like adhd. ”

They Also Measured Neurofilament Light Chain (NFL) Levels in the Blood Plasma, to determine the neuroaxonal integrity – Health of the Nerve Cells – in the brain. Raised Nfl Levels in Blood Plasma Indicate Damage to the Nerve Axons (Fibers).

High Brain Iron Levels, Adhd, and Alzheimer’s

In participants with adhd, high Iron Levels were detected in the Cortex precentral – The Area of ​​the Brain That Controls Voluntary Movement – The Cerebral White Matter, Which is responsible for Communication Between Nerve Cells to Enable Cognitive Functions and Several Other Structures in the Brain.

“It is important that we Begin to pick up that man and disorders of the nervous system are co-morbid and share similar mechanisms of injury, like while matter and neuronal Damage. Risk Factors That these disorders share. “
– Marissa Sobolewski

As Well As Having Higher Iron Levels Than Individual Control, Those with Adhd Had Raised Nfl Levels in Their Blood Plasma, Damage Neuroaxonal Indicating. Studies Have Found That People in The Early Stages of Alzheimer’s Disease Have Increased NFL, A Biomarker of Neurodegenerative Brain Change, in Their Brain Fluid, As Well As In Their Blood.

ALLDER EXPLAINED:

“Iron plays a crucial role in neurotransmitter synthesis, specially dopamine, which is already Known to be dysregulated in adhd. However, excess Iron can lead to oxidative stress, Damaging Neurons and possibly accelering neurodegeneration.”

“High Iron Levels Can Promote Oxidive Stress, Which May Damage Neuronal Axons. This Aligns with the Increased Nfl Levels Found In Adhd Patients, Which Indicate Axonal Injury,” He Added.

What are the symptoms of adhd?

ATTENTION DEFICIT HYPERActivity Disorder (ADHD) IS A USALLY DIAGNOSED DURING CHILDHOOD, BUT MAY CONTINUE INTO, OR BE DIAGNOSED IN ADULTS. In adults, it is characterized by or all of the following symptoms:

  • Difficulty Paying Attention, Being Easily Distracted and interrupting people
  • Problems with Organization, Following Instructions, and Complesting Tasks
  • Restlessness and Difficulty Sitting Still
  • Forgetfulness
  • Easily Becoming Irritable, Impatient, or frustrated
  • Difficulty Dealing with Stress
  • Impicive Behavior.

According to the CDCexperts are Still Unsure What Causes Adhd, But Genetics May Play A Role, As Maynal Exposure to Environmental Factors Such As Lead, Alcohol and Tobacco During Pregnaancy, and Head Injury.

Studies Have Found That People With Adhd May Have Widespretad Micro-and Macro-Structural Differences In Their Brain From People Without This Diagnosis.

Could Iron Reduction reduce Dementia Risk?

The authors suggest that in adult adhd, there may be a link Between excess brain Iron and neuroaxonal vulnerability, possibly mediated by oxidative stress, which could accounts for the association Between adult adhd and dementia.

“If adhd-related brain changes persist into adulthood, the combination of oxidative stress, inflammation and neuroaxonal vulnerability could increases susceptibility to neurodegenerative condions like Alzheimer’s.

– Steve Allder

The Authors ACKNOWLEDGE Limitations in Their Study, particularly that a cross-section Study, It Cannot Detect Changes in Participants Over Time.

However, Unschuld suggests that their findings might enable targeted prevention Strategies to be developed to reduces the risk of dementia in persons affected by adhd.

In a Press Relay, I have strain for longitudinal studies “to determine if a reduction of Iron Levels in the brain is a potential Treatment Pathway for Preventing Dementia at an advanced age in persons with adhd.”