Taking Longer to Get To Rem Sleep Coul Indicate Alzheimer’s Disease

The National Institute of Neurological Disorders and Stroke State that “Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) refers to the Most Common Forms of Dementia.” Dementia Does Not Have A Cure, But Research into potential Risk Factors and Early Detection Remains Ongoing.

The Authors of The Current Study Wanted To Understand More About The Timing of Rem Sleep and its Relationship to Alzheimer’s Disease and Alzheimer’s Disease and Related Dementias. is a Stage in the Sleep Cycle When Vivid Dreaming Occurs. REM SLEEP HELPS WITH INFORMATION PROCESSING AND CONSOLIDATION.

Rem Latency (REML) IS THE AMOUNT OF TIME IT TAKES FOR SUBSE TO REACH REM FOR THE First TIME AFTER FALLING ASEEP.

For This Study, Refectchers Examined Rem Sleep, and Several Biomarkers Refers Noted Were Associated With Alzheimer’s Disease and Alzheimer’s Disease and Related Dementias.

This Research Included 128 Participants. Sixty-Four of the participants had Alzheimer’s Disease, Forty -one Had Mild Cognitive Impairment, and The Rest Had Normal Cognition. All participants were at least Fifty Years Old. Azheimer’s Disease, Refrachers Excluded participants who had other neurodegenerative disorders Like Parkinson’s Disease. They Also Had Several Other Exclusion Criteria, Such as Sleep-Related Movement Disorders or The Use of Antipsychotic Drugs.

Refrachers Colleced Data On Participants’ Medical Histories, and All Participants Underwent Cranial Mris, Bloodwork, and A Number of Cognitive Tests Before the Start of the Study.

Participants Did An Overnight Sleep Study Called Polysomnography, which can examine Brain Waves and Other Physical Functions Like Eye Movement and Breathing During Sleep. Researchers Were Uble to Identify When Participants’ Rem Sleep Occurred.

Participants underwent pet scans to look at Amyloid Beta Levels, which can indicate Alzheimer’s Disease. Refrachers Also examined the Levels of Three Plasma Biomarkers. You increase in plasma phosphoryled tau at threonine 181 (p-tau 181) May indicate Alzheimer’s Disease, and increases in neurofilament light (NFL) May indicate neurodegeneration. DESERVES IN PLASMA BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) CAN ALSO Indicate Alzheimer’s Disease.

Refracchers Also driving Statistical Analysis, Adjusting for Factors Like Body Mass Index, Sex, and Diabetes Mellitus. They also adjusted for APOE ε4 Status, which is a gene that can increased sumone’s risk for Alzheimer’s Disease.

How Delayed Rem Sleep AFFFETS THE BRAIN

The Study’s Results Reveared That Participants With The Longest Reml Had Higher Levels of P-TAU181 and Amyloid Beta and Lower Levels of Plasma Brain-Dernedd Neurotrophic Factor Comparated to participants with the shortest reml. These results were Independent of Participants’ Cognitive Status Or Apoe ε4 Status.

Even after adjusting for the possibility of false positive results, The Link Between Amyloid Beta and Plasma Brain-Derned Neurotrophic Factor-A Protein Involved in Brain Cell Growth-Remaled Significant. This suggests to Meaningful Link Between these two factors that could be significant for understanding alzheimer’s disease.

ADDITIONALLY, HAVING LESS REM SLEEP AND DEEP SLEEP (ALSO KNOWN AS SLOW-WAVE SLEEP) WAS LINKED TO HIGHER LEVELS OF P-TAU181, A PROTEIN ASSOCIED WITH SLOW-WAVE SLEEP IS THE STAGE OF SLEEP WHEN PEOPLE EXPERIENCE THE DEEPEST REST. However, This Association Did Not Remain Significant Consideration The Possibility of False Results.

Study Author Yue Leng, PHD, Associate Professor at the Department of Psychiatry and Behavioral Sciences, Bakar Computational Health Sciences Institute (BCHSI), University of California, San Francisco, Note The Following To Medical News Today:

“Rem Sleep, Specially The Time It Takes to Enter Rem Sleep, Is Potentially Important For Alzheimer’s Disease. The importance of This Sleep Metric Has Been Largely Ignored Previously. We Don’t Know if the correlation is causal, but rembe lanncy can potentially serve as a Marker and Help with the Early detection of ad (Alzheimer’s Disease). More Research is Needed to Understand the Biological Underpinnings of Rem Sleep Latency and its Implications for Ad (if the Relationship is causal).

This Research has a FEW Limitations. First, It Cannot Establish that Delayed Rem Sleep is a cause of Alzheimer’s Disease. Since it was Cross-Sectional, It Also Cannot Note The Direction of the Associations It Identified.

It also include Fairly Small Number of Participants, All Han Chinese and At Least Fifty Or Older. The Number of Participants in Each Diagnosis Group was Also Small, and This Could Have Limited The True Statistical Power Needed To Compare “Associations by Cognitive diagnosis.”

While Refers Did Find That Participants With Mild Cognitive Unpaid or Alzheimer’s Disease Took Longer To Get To Rem Sleep than Participants Without Cognitive Impairment, Those Results Did Not Reach A Statistics Significant Level.

Future Research Coul Benefit from Studies with Larger Sample Sizes and Greater Diversity, as Well As From including youunger participants.

Researchers Also Chose To Focus on Plasma P-Tau 181 INSERAD OF P-TAU217. They note that p-tau217 is more sensitive to predicting Alzheimer’s Disease Progression.

The Setting for The Sleep Study Could Have Led to Environmental Disturbances, Which Could Have Affected Sleep Measurement Accuracy. Additionionally, since the Sleep Study Was Only One Night, It Might not Totally Reflect What participants’ Sleep Patterns Typically Look Like. Researchers Also Note That Many Participants Did Not Have A Percentage of Sleep Time That Was Slow-Wave Sleep, and This Could Affect The Ability to generalize The Results.

One of the Study Authors declared Conflicts of Interest, and The Study Received Funding Support from Two Grans.

Giulio Tagliaratela, PHD, Vice President of Brain Health, director of the Moody Brain Health Institute, Research Professor, and the Lawrence J. of Pope distinguished chair in neurodegenerative dessearar Research Professor With the Utmbment Department of Neurology, Who Was Not Involved in The Study , Note The Following about the Study’s Findings:

“(It is) a Well-Conducted Pilot Clinical Study That Suggests that the delay to the first remote is associated with increased Alzheimer’s Disease Biomarkers. While The Observation is Interesting and Diving Further Development, The Current Study is on Limited Number of Patients, Compressing its Full Statistical Power. “

This Study Highlights How Rem Sleep is Likely Also Important When it comes to dementia Research and not just slow-wave syleep.

Alex Dimitriu, MD, Double Board Certified in Psychiatry and Sleep Medicine and Founder of Menlo Park Psychiatry & Sleep Medicine, Who Was Also Not Involved in the Study, Notted:

“The Findings in This Paper Shift the Focus from Slow-Wave Sleep To Rem Sleep As Another Area of ​​Research In Alzheimer’s Disease. More Generally, these Findings Add Weight to the importance of All Stages of Our Sleep Cycle, Including Rem Sleep. ”

Overall, More Research is required to understand the full clinical implications of the data. However, it’s a possibossing prolonged remiplesing remlid could potentially modify the risk for Alzheimer’s Disease and Alzheimer’s Disease and Related Dementias. Identifying prolonged remld Also Help with Celerin Dementia Detection Early On.

“RELATIONSHIPS BETWEEN SLEEP PATTERNS AND RISK OF DEVELOPING DEMENTIA HAEN NOTIED IN THE PAST. This Study Points to a A Specific Disturbation (Delayed First Rem Episode), Shedding Sub light on the spect of Sleep/Dementia Connection. MONITORING Delayed First Rem Episodes represent Marker to Predict Later Development of Dementia. However, Many More Studies Are Needed to Bring This Observation to Clinical Reavence. “
– Giulio Tagliaratela, PHD