- Telomeres, The Protective Caps at The Ends of Chromosomes, are an important component of Healthy Aging.
- One Study Found That Vitamin D Supplementation Helps To Minimize The Shortening of Telomeres, Which Happens As People Get Older, and Thus May Protect Against Diseases Tied To Age and Biological Aging.
- This data adds to the potential protection components of vitamin D, Which experts should considered potential pill risks and addional research.
A Study Published in The American Journal of Clinical Nutrition Examined Howa-3 Fatty Acid and vitamin D Supplementation AFFEED TELOMERE SHORNING, A NATURAL PROCESS THAT HAPPENS WITH AGE.
As The Authors of this Study Explanred,
David Cutler, MD, A Board Certified Family Medicine Physician At Providence Saint John’s Health Center in Santa Monica, Ca, Who Was Not Involved in The Study, Told Medical News Today THE “WHEN TELOMERES BECOME TOO SHORT, CELLS ENTER SENESCENCE (A NON-DIVIDING STATE) OR APOPTOSIS (PROGRAMMED CELL DEATH). EITHER CONDITION OF CELL INACTIVITY OR DEATH IS THOUG TO CONTRIBUTE TO AGING AND AGE-REALATED DESIGNS.
The Researchers Found That Vitamin D Supplementation Helped Minimize Telomere Shortening in White Blood Cells, Which Could Help Slow Down Biological Biological Aging.
Vitamin D Supplementation Impacts Telomere Length
For This Study, Refrachers used data from the vital trial. This trial included to Representative Sample of Adults in the United States Who Received Vitamin D3 Supplements, Omega-3 Fatty Acid Supplements, Ort Both for Around Around Five Years. It was a Double-Blind, Placebo-Controlled Study, So Sub participants prescribed the supplements WHILE OThers Received The Placebo. All female participants were at least Fifty-Five Years Old, and All Male Participants were at least Fifty.
This Data Specifically examined Cohort That Visited The Harvard Clinical and Translation Science Center. At Baseline and Follow-up visits, participants participated in in-person assesments and provide fasting Blood samples.
Refrachers examined Telomere Length in
Researchers Were Uble to Analyze Over 2,500 samples from OVER 1,000 participants. They examined Telomere Length at Baseline and at Two-Year Follow-Up, Though I Sub Data was missing.
They conduct to Statistical Analysis Using Models to Adjust for Various Covariates. They Also Did An Exploratory Subgroup Analysis to See Different Factors, Such As High Blood Pressure and Diabetes, Impacted Results.
Vitamin D vs. Omega-3 Fatty Acids
I assign from Higher Body Mass Index in the Omega-3 Fatty Acid Supplement Group, The Placebo and Intervention Groups had similar Baseline Characteristics. Missing Data was also Between The Two Groups.
Vitamin D Appeared to have positive impact on telomere length. Among Participants Who Received Vitamin D, There Was Only Minimal Shortening of Telomere Length at Two and Four Years. In contrast, There Was Substantial Telomere Shortening in the Placebo Group At Bu -Time Points.
Omega-3 Fatty Acids Supplementation Appeared to have not significant impact on telomere length.
The Subgroup Analysis Further suggesta that the Effects of vitamin D on Telomere Length were significant for participants not Taking Medication for Cholesterol, But not for participants Who Were Taking Cholesterol Medication. Vitamin D Also Minimized Telomere Shortening at a Statistics Significant Level for Non-White Participants.
There was not meaningful interaction with body mass index, but showchers Did observe that participants who were not obese had significantly minimized telomere shortening. Also, Taking Omega-3 Fatty Acid Supplements Did Not Appear to Impact The Role of Vitamin D on Telomere Length.
Study Limitations
This Analysis of Telomere Length in This Study Population Does Have Sub Subs Limitations. First, Most Participants Were White, and All Participants were at least Fifty, So it may not be positive to generalize the Findings to Other Groups.
Researchers acknowledge that This was a post-hoc analysis of an already completed study and that the study was not originally designated to look at the efforts of supplements on leukocyte telomere length. The Analysis Also Excluded participants Who Did not have data on leukocyte telomere length.
It’s possible that unaccouted-force factors influenced the results, and the study Also has any other limitations Found in the original Study.
RECGRDING EXPLORATORY SUBGroup Analysis Results, Refectchers finding caution, Note Limited Power, and Say People Should Look at The Data As “Hypothesis-Geneling.”
After Four Years, There were about 37% Missing Cases. Researchers ACKNOWLEDGE THAT this Reduced Power and Could Be Why They Did Not Find Omega-3 Fatty Acid Supplementation AFFEED LEUKOCYTE TELOMERE LENGTH.
Future Research Can Explore Why Vitamin D May Have BeSe Effects On Telomere Length. For Example, it could be related to an enzyme street Telomerase that Helps to Lenghen Telomeres and How Vitamin D May Protect Against Dna Damage.
CUTLER ALSO NOTED THE FOLLOWING LIMITATIONS OF THE STUDY:
“The present Study Involved Only a relativley Small Number of People, Looked Only at Telomeres in White Blood Cells, and Did Not Look Extensively at The Health Impact of these Telomere Changes. So, The Clinical Implications One Can Derive from This Study Are Quite Quite Limited.”
Vitamin D May Slow Aging by ‘3 Years’
This Study Suggests The Potential Benefits of Vitamin D in Relation to Aging. The authors suggest that the preservation of Telomere Length in This Study “Could Mean A 3-YEAR Decree in Aringing.”
Yoshua Quinones, MD, A Board-certified Interist With Medical Offices of Manhattan and Contributor to https://www.labfinder.com/, Who was also not Involved in the study, note the following to MNT:
“As We Know Already, Vitamin D Supports Bone, Immune System and reduces inflammation, but This Study is Linked Directly with Telomere Preservation Which Ties Tent Aging and Disease Prevention. Your Bones But Actually Slowing Down The Cellular Age, Impressive! ”
“IF this is confirmed in future studies, This Could Mean That Daily (Vitamin D} Supplements Coud Actually Help Reduces Risks for Age-Relaged Diseases.
– Yoshua Quinones, MD
However, It’s also important to note the potential risks of vitamin d supplementation.
“While 2,000 units of vitamin d is unlikely to have any negative effects, there may be subject to vitamin d supplements as they can cause Kidney Damage and other adverse effects in excessive quantities. Since vitamin d is fat soluble, it can Potential, As Yet Unproven Benefits of Vitamin D Need To Be Weighed Against ITS KNOWN RISKS, ”CUTLER SAID.
