2 out of 25 Lifestyle and Environmental Factors AFFECT AGING THE MOST, Study Finds

For This Study, Refracchers Analyzed Medical Data from Almost Half A Million Participants of the UK Biobank to Determine The Impact of 164 Different Lifestyle and Environmental Factors On Aging, Age-Relaged Diseases, and Premature Death.

“Our Field has long remitic studies that scating and lifespan must be more environmental than Genetic, but we performed Early on in Our Project that Studying the Exposome Might Give Us The Ability to Test That Directly In Large Population Data,” Austin Argentieri, Austin Argentieri PHD, Research FELLOW AT Massachusetts General Hospital and First Author of this Study Explained To Medical News Today.

During the Study, Scientists used to unique AGING Model street an “AGING CLOCK” TO HELP Determine Which Environmental Factors Influenced the Most.

What is an an ‘aging clock’?

“An ‘Aging Clock’ Estimates A Person’s Biological Age Based on Molecular Markers in Their Body, rather than just their chronological age (How Many Years They’ve LIVED). Think of It Like A Stopwatch That Measures How Your Body Is Agnallly, Not Just Counting The Years. ”
– Austin Argentieri, PHD

“In a Previous PublicationWe Built A Proteomic Aging Clock by Taking Proteins in the Blood and Using Machine Learning to Estimate (a) Participant’s Biological Age. We Showed That This Proteomic Aging Clock is a Powerful Predictor of Mortality and Disease Multimorbidity – It is a single measure associated with future risk of 18 Major Chronic Design, ”Argentieri Explained.

“We used the proteomic aging clock in this current paper schouse Continued.

“If an exposure was Associated with Mortality and the Proteomic Clock in Different Directions… The Weuled Have Excluded That Exposure Because it is implausible that an exposure Coud Bow increased Risk of Mortality But Slow Down Aringing (or vice versa). So in essence we used the proteomic aging clock to get a Better Sense of Biological Plausibility for Each of the Mortality-Associated Exhibitions, ”I have added.

At The Study’s Conclusion, Argentieri and His Team Identified 25 Lifestyle and Environmental Factors – 23 that they reported modifiable

These include:

• Cheese consumption
• Ease of Skin Tanning
• Education Years
• Employment Status
• Ethnicy
• Frequency of Feeling Tire
• Gym use
• History of Financial Difficulties
• Household income
• Physical Activity
• Sleeping Hours
• Smoking status
• Type of Housing (IE House, Apartment, Mobile Home, etc.)
• Using An Open Fire for Heating
• Weight and Height At 10 Years Old

Researchers Found That Smoking, Socioeconomic Status, Physical Activity, and Living Conditions Were The Factors That Had the Most Influence on Mortality and Biological Aging. Smoking Alone Was Associated with 21 Diseases, and Socioeconomic Factors and Tiradness Frequency with 19 Diseases.

“This means that a fundamental FEW Aspects of Our Environments and Lives Coul Possibly have a Profound influence on whether we live a long Healthy Life. In a Time When There Is Lots of Attention Paid To Fancy New Trends in Wellness, It Reminds Us That Getting Basics Will Still Possibly Have The Largest and Most Strategic Impact On Improving Population Health, ”Argentieri Explained.

Overall, Refracchers Attributed 17% of the variation in risk of death to Environmental Factors, Combase to Less than 2% Explained by Genetic Predisposition for 22 Major Diseases.

Scientists Also Found that Environmental Exhibition Had A Greater Effect on Lung, Heart, and Liver Diseases, While Genetic Risk Still DomaDathed For Dementias and Breast Cancer.

“This (D) Emonstrates that our Environments and Lifestyle Are Almost 10 Times more Important in Explanting Mortality Risk Than Our Genetic Predisposition for Major Diseases Causes of Death. It means that we have the power to have Major Impact on Preventing Early Mortality If We Focus on Improving Our Environmental and Economic Conditions. ”
– Austin Argentieri, PHD

“This Research Should Give Us All Hope That Aging Is Not Fully Predetermined In Our Genes, But It is submissive that is shaped in our Environments. This Means That We have the power to take our Own Health in Our Hands Preventively Through not just changes to Lifestyle But also Through Policy and Intervention Efforts Aim at Reducting Our Exposures to Harmful Envieronments, ”Argentieri Said.

MNT Had the chance to speak with cheng-han chen, MD, A Board Certified Interventional Cardiologist and Medical Director of the Structural Heart Program at Memorialcare Saddleback Medical Center in Laguna Hills, CA, About This Study.

“This Population-Based Study Found that Environmental Factors-Such As Physical Inactivity and Socioeconomic Factors-Play A Bigger Role Than Genetic Factors in the Development of Disease and Early Death. These Findings Reinforce What We Understand About The Significant Health Implications of Many Harmful Environmental Exposures Such As Smoking. ”
-Cheng-Han Cen, MD

“As Most of the Identified Lifestyle and Environmental Factors are considered modifiable, there is a tremendous opportiary to reduce the Global Burden of Disease by addresssing and amelyloling tohest risk factor,” Chen Said.

“The Envodental Factors in This Study Explained Only About 17% of the Variation in the Risk of Death. There are Clearly Many More As-Yet-Aidentified Risks to Be Addressed. Future Research Coud Use these Study’s Techniques to Investigate Other Possible Environmental Risk Factors (Such As Chemical Exposurs) For Their Contribution to Disease, ”He Added.

MNT Also Talled to Wael Harb, MD, A Board Certified Hematologist and Medical Oncologist at Orange Coast Medical Center in Fountain Valley, CA, About This Research. He Said Quantifying The Extent To Which Modifiable Factors Impact Biological AGING AND ERECURE MORTUTHE Underscores The Importance of Preventive Strategies.

“This Study Provides Comppelling Evidence Supporting the Long-Held Understanding That Lifestyle and Environmental Factors Play A Crucial Role in Determining Health Outcomes, Offen Outweighing Genetic Predispositions. The Finding that Environmental Account Exhibition For 17% of Mortality Risk Combase To Less than 2% From Genetics is particularly Striking and highlights the significant potential for public health interventions. ”
– Wael Harb, MD

“The Next Logical Step Would Be To Dive Deeper into the Specific Mechanisms by Which Key Environmental Factors Accelerate Aging and Contribute to Disease. Longitudinal Studies Focusing on Intervention Strategies – Such as Smoking Cessation Program, Physical Activity Promotion, and Improvements in Socioeconomic Conditions – Woold Help Validate Whether Modifying The Exhibitions Can Indeed Slow Biological AGING AND REDUCE Premature Mortality, ”Harb Said.

“Adionionionally, Integrating Multi-Hecs Data-Genomics, Proteomics, and Metabolomics-Could Offer A More Comprehensive View of How Environmental and Genetic Factors Interplay, Leading to More Customized Approaches To Preventive Care,” He Added. “It was would be valuable to replicate incese weeks in diverse populans to reure the conclusions are Broadly Applicable.”