- Menopause – The End of a Woman’s Reproductive Years – Can Bring A Range of Symptoms, Including Hot Flashes, Night Sweats, and Brain Fog.
- Hormone Therapy, To Boost The Levels of Hormones That Decree Arund This Time, Can Help to Allevavate Symptoms.
- Now, A Study Has Found That Estradiol, A form of estrogen, May Improve Cognition and Memory, But the Specific Effects Vary with the Mode of Administration.
- Women Using Transdermal Estradiol (Patches or Gels) Showed Improvements in Episodic Memory, and Those Oral Taking Estradiol Had Improved Prospective Memory.
Menopause Signals The End of a Woman’s Reproductive Years, Occurring 12 Months After the last menstrual period.
During the Years Leading Up To and Following Menopause Many Women Experience Symptoms Including Hot Flashes, Night Sweats, Vaginal Dryness, A Reduced Sex Drive, and Problems with Concentration and Memory.
To allevavate symptoms, to Woman May Take
Now, A Study You have found that Estradiol Therapy May Not only Help with Vasomotor Symptoms, But Couls Also beneficial Effects on Memory.
The Study, Published in Neurology, The Medical Journal of the American Academy of Neurology, suggests that transdermal estradiol (Patches or gels) you have different memory effects that than oral stradiol. The Researchers Found that transdermal estradiol Improved recall of past experiences, oral oral stradiol improved ‘ability to remembero to do future tasks.
“This Study Highlights The Discrepancies on Hormone Therapy Influence on Cognition, The Varying Effects On The Type of Estrogen used, The Association Between When a person goes into men Therapy and Cognition. “
– Sherry Ross, MD, Board Certified Ob/Gyn and Women’s Health expert at providence Saint John’s Health Center in Santa Monica, ca.
POSITIVE MEMORY EFFECTS FROM HORCONE Therapy
The Researchers used data from 7,251 post-Menopausal Women. and self-identified as female) in the longitudinal Canadian Study on Aging (CLSA) in Their Cross-Sectional Study. At The Start of The Study, The Women, Who Had Undergone Menopause at an average of 50.5 Years, Were An Average of 60.5 Years Old.
All participants Underwent A Number of Tests of Cognitive Function. You are Assesed:
- Episodic Memory – The Ability to Form, Store, and Recall Conscious Memories of Specific Past Events
- Prospective Memory – The Ability to Remember to Perform A Planned Action or Trying in the Future.
- Executive Function – Mental Process Needed for Planning and Problem Solving.
For All The Participants, An Earlier Age of Menopause was Associated With Reduced Performance on All Three Areas of Cognitive Function.
In total, 6% of the cohort were using estradiol (E2) Therapy – 4% transdermal and 2% oral – at the time of testing.
Women Using Transdermal E2, But Not Oral E2, Performed Better On Episodic Verbal Memory (Word List Recall). Oral e2 those E2 Had Better Prospective Memory (eg. Remembering an appointment, or to take a medication), Combase with those Who Had Never used E2. Neither Therapy Had Any observed Effect on Executive Function.
Anand Singh, Consultant Gynaecologist At The Cadogan Clinic, London, Suggesta The Study Found No Impact On Executive Function:
“Executive functioning depends on complex networks in the prefrontal cortex, which may be les sensitive to estrogen levels in midlife compared with memory-related regions Like the hippocampus. In This Cohort, Most Women were Cognitively Healthy, Leaving Limited Limited Scope Sched Improvement in Executive Function. “
“Adionionionally,” He Told Medical News Today“Cognitive Benefits May Require Early or Prolonged Exposure to Menopausal Hormone Treatment (MHT), and The Average Duration and Timing of Therapy in This Study May Not have been sufficient to produce detectable Effects.”
He also suggested that “The Tests used for memory are offen more sensitive to Hormonal Subtle Influences than Those Assessing Executive Function, Which Could Explain The Lack of Observed Effects in This Domain.”
MODE OF ADMINISTRATION MAY CHANGE EFECTS ON MEMORY
Study Author Liisa Am Galea, PhD, Of The Center For Addiction and Mental Health in Toront MNT:
“When we take drrugs orall hormones, they undergo chemical breakdown in the liver and This can alternate the drrugs/hormone work. In the case of estradiol taken orally it converts to a les potent strogen street stroke. Strone is not as efficient at interacting with the strogen receptor.”
Estrogen Patches vs. Pills
“We Don’t Know The Reason Transdermal Estradiol Leads To Better Episodic Memory But It Could Be The Number of Estrogen Receivers in The Temporary Medial Lobe Which is the Brain Region Important for Episodic Memory (and estradiol interacting Withm More effectively).”
– Liisa Am Galea, PhD
Ross AgreeD:
“The More Stable and Efficient Transdermal Estradiol has benefits of a First-Pass Metabolism, Bypassing the Liver, which May Also Support The Area in the Brain Dependent on Memory. Less Effectively Than Transdermal estradiol.
Modest Cognitive Benefits Highlight Need for Further Studies
Galea Emphasized that None of the Estradiol Therapies were Associated With Reduced Memory.
The Authors ACKNOWLEDGED SIVERAL LIMITATIONS OF THE STUDY, INCLUDING THAT THE WOMEN USING HORMONE TREATMENT WERE PREDOMINANTLY WHITE, AND WEALTHIER. The Study Also Focused Only On E2S, Not Any OTher Hormones used for menopause Treatment, and Did Not Differentiate Between Thue Taking Only E2 and Thue Using It Together With Progestagens. Also, Because of ITS Cross-Sectional Design, The Study Cannot Prov Any Causative Effect.
However, Ross Emphasized that Memory Improvements Could Be a Benefit of Hormone Therapy for Menopause:
“Brain Fog and Cognitive Decline Are Common Symptoms in Menopause and With Aring.
“Estradiol Therapy Remains A Powerful Tool for Managing Menopausal Symptoms, But Cognitive Benefits Are Modest and Domain-Specific, and Risks Vary by Formulation, Timing and Individual Patient Factors.
Transdermal Administration May Offer the Most Promising Profile for Memory Support, But Further Longitudinal Studies Are Needed To Clarify Long-Term Cognitive Outcomes. ”
– Anand Singh
