• Around Half of All People Will Have A Cancer Diagnosis at Sub Stage In Their Life, Most Commonly in Their Later Years.
  • CANCER THAT IS CONTINED TO ITS ORIGINAL LOCATION IS EASIEST TO TREAT, BUT CANCER CELLS CAN BREAK OFF AND SP PREAD TO OTHER PARTS OF THE BODY.
  • Scientists Studying How Concers Spread Have Found That Aspirin May Help Prevent Metastases, Or Secondary Tumors, By Boosting The Body’s Immune Response.
  • In Their Mouse Study, Aspirin Helped Immune Cells to destroy spreading cancer Cells.
  • Research is underway in People to investigate whether aspirin, or draget the Same Pathway, could be used to help stop or delay the return of cancers.

According To Cancer Research UK, Half of All Those Diagnosed with Any Type of Cancer In Wales and England Will Survive for At Least 10 Years After Diagnosis, and The Proportion Is Much Higher for Sub of the More Common Cancers, Based on Data From 2010-2011.

Based on data from 2013-2017, More than Three Quarters of Those with A Breast or A Prostate Cancer Diagnosis In England Will Be Alive 10 Years Later.

Key to Successful Treatment is Early Diagnosis, Before The Cancer Has A Chance To Metastasizeor spread, from its original location. More than 90% of Cancer Deaths Happen after cancer you have spread to another part of the body.

Now, Scientists from the University of Cambridge, United Kingdom, have discovered that aspiin, Cheap, Widely Available Painkiller, Could Prevent Sub Types of Cancer From Spreading, and How It Might Do This.

The Study, Published in NatureFound that, in Mice, aspiin acted on plalets – The Tiny Cells That Cause Blood To Clot – Making Them produces Less of a Clotting Factor, Thromboxene A2 (Txa2) That Supresses Immune t Cells. With Less Txa2 SUPPRESSING THM, You are t cells canch destroy any spreading cancer cells.

Niles Vora, MD, A Board-Certified Hematologist and Medical Oncologist and Medical Director of the Memorialcare Todd Cancer Institute at Long Beach Medical Center in Long Beach, CA, Not Involved in the Study, Told Medical News Today How Important This Study Is:

“It generates to valid hypothesis on How to Prevent Cancer Recurrence and Sp pread, using A Vary Easy to provide intervention for patients. The Key Part of This Articles Is: Aspirin Prevents Cancers from Spreading by DECREASING TXA2 and RELEASING T Cells from SUPPRESSION. “

Study Focuses on Cancer ‘Window of Vulnerability’

There Have Been Hage Advances in the Treatment of Early-Stage Cancers, But There is Still A Risk of Recurrence Elsewhere In The Body If Cancer Cells Have Migrated from The Site of the Original Tumor.

Inside The Microenvironment of the original tumor, The Immune System is suppressed so is les cass to Kill Cancer Cells. However, eleven these lone cancer Cells Migratrate, The Immune System Can Target Them.

Rahul Roychoudhuri, PHD, Lead Author of The Study, and Professor of Cancer Immunology at The University of Cambridge, Told MNT That:

“When Cancer First Spreads There’s a Unique Therapeutic Window of Opportunity When Cancer Cells are particularly vulnerable to Immune Attack. We Hope That Therapies That Target This Window of Vulnerability Will have tremendous scope in preventing recurrence in patients with Early cancer at risk of recurrence. ”

Surprising New Use for Old Drug

The Refrachers Had Previous Found 15 Genes In Mice That Had an Effect On Cancer Goalstasis. They Found that Mice Lacking A Gene Which produces Protein Calleed Arhgef1 Had Lessasis of Sub Primary Cancers in the Lungs and Liver. From This, The Worked Out That Arhgef1 Supresses T Cells That Kill Metastatic Cells.

They have discovered that This genes is switched on when Cells are exposed to the clotting factor txa2.

Aspirin inhibits The Production of Txa2 By Palelets, Which Is Why People Subtimes Take It At Low Doss Recent evidence NOW CONTRADICTS THE DATA ON HEART ATTACK AND STROKE PREVENTION.

In The Current Study, looking at the mouse model of melanoma – An Aggressive Form of Skin Cancer – The Researchers Found That Mice Which Received Aspirin Developed Fewer Metastases Than Control Mice. The Aspiin Release their t Cells from Supression by Txa2, Enabling Them to Kill Cancer Cells.

“It was a Eureka Moment when we found txa2 was the molecular signal that active This suppressive effect on t cells,“ Said Jie Yang, PhD, One of the Study Co-Authors, Based At The University of Cambridge, in a Press Relay.

“Before This,“ Yang Note, “We had not Been Aware of the Implication of Our Findings in Underestanding The Anti-Metastatic Activity of Aspirin. It was an entirely unexpeted finding which feels down remove Different Path of Enquity Than We had anticipated. ”

Do The Findings on Aspirin and Cancer Also Apply to People?

Yang Emhazied The Potential of the Research Team’s Findings, Noting That “Aspirin, Or Other Drugs That Could Target This Pathway, have the potential to be be lessive exhibition than antibody-base therapies, and therefore More accessible globally.”

However, The Researchers do Caution That Aspirin Can Have Side Effects and May Not Be suitable for Everyone. Commonly, aspirin can cause stomach or gut irritation, nausea, and indigestion.

OHER SIDE EFFECTS THAT ARES COMMON INCLUDE WORSENING ASTHMA Symptoms, Vomiting, Stomach Inflammation or Bleeding, and Bruising. Rarely, and Privately in Those Taking a Daily Dose, It May Cause Bleeding in the Brain, Kidney Failure Or Haemorrhagic Stroke.

Anton Bilchik, MD, PHD, Surgical Oncologist, Chief of Medicine and Director of the Gastrointestinal and hepatobiliary program at providence Saint John’s Cancer Institute in Santa Monica, CA, Not Involved in This Research Welcomed The Findings, But Told MNT that they must be validated in clinical trials with human participants:

“Clearly Clinical Trials Need to Be Done To Validate Tohese Findings. Both Aspiin Alone in Patients Who Have Earlier Cancers, and Therefore not candidates for Immunotherapy or Chemotherapy, and aspiin as an adjunct to before Therapies in More Advanced Cancers Need to Be Evaluated.

The Good News is Clinical Trials in People Are Now Under Way. The Refrachers Will Be Collaborating With Ruth Langley, MD, Professor of Oncology and Clinical Trials in the MRC Clinical Trials Unit at University College London, Who is Leading The Add-Aspirin Clinical Trial, to find out if aspiration can stop or delay the Return of Early Stage Cancers.

Langley, Who was not involved in the current study, Advised that People Should Start Taking Aspirin Only On Doctors’ Advice.

“In A Small Proportion of People, Aspirin Can Causeus Side-Effects, Including Bleeding Or Stomach Ulcers. Therefore, it is important to understand which People with cancer are Likely to Benefit and Always Talk to Your Doctor Before Starting Aspirin, ”She Emphasized.