- As MANY AS 70 MILLION PEOPLE AROUND THE WORLD LIVE WITH A SLEEP DISORDER.
- Sleep Disorders Can Impact a Perso’s Risk For Several Health Conditions, Including Dementia and Alzheimer’s Disease.
- A New Study Has Found That A Medication Commonly used to Treat Insomnia May Not Only Improve Sleep Quality, But Also Protect The Brain From A Buildup of the Protein Tau, via Mouse Model.
Researchers Estimate That As MANY AS 70
Not getting Enough Sleep Every Night Can Take ITS TOLL ON THE BODY BY NEGATIly AFFECTING A PERSON’S ABILITY TO CONCENTERT AND THESE MENTAL HEALTH.
PAST STUDIES ALSO SHOW SLEEP DESCORDERS CAN INCREASE TO PERSON’S RISK FOR SIVERAL HEALTH ISSUES, SUCH AS HEART DIRECT
“Poor Sleep Quality and Sleep Disorders offe of the Hope Center for Neurological Disorders at The Washington University School of Medicine Told Medical News Today.
“Research from Our Lab and Others Has Shown That Disrupted Sleep Elevates LEVELS OF BOY
He is the senior author of a new study published in the journal
How Does Lemborexant Afphet tau in the brain?
For This Study, Focused on a Sleep Disorder Medication Lemborexant, Sold Under The Brand Name Dayvigo.
“Lemborexant Belongs to a Class of Sleep Medications Calleed Dual Orexin Receiver Antagonists,” Samira Parhizkar, PHD, Instructor at Washington University School of Medicine, and First Author of This Study, explained to MNT. “Beghe Drugs By Blocking Orexin – A Protein in The Brain That Keeps Us Awake and Alert.”
“By Blocking The Orexin Signaling, The Medication Allows Sleep To Deco Quickly and More Easily,” Parhizkar Continued. “In Other Words, if your brain is like a light switch that keeps ficking on when you are trying to Sleep, Lemborexant Helps Turn that Switch off, So Your Brain and Body Gets the Rest It Needs.”
Scientists used Lemborexant To Treat A Model of Mice That Were Genetically Prone to Having Tau Buildup in the Brain.
“In the Healthy Brain, Tau Protein Acts As a ‘Track’ that Helps Support the Shape of Cells and Helps Move Nutrients and Signals Where they need to go,” Holtzman Detailed.
“In alzheimer’s and a group of neurodegenerative disorders primarily affected by abnormal tau street tauopathies, abnormal tau loses it Shape, integrity and therefore cellular functionality leading to tau tangles Death that contribute to Memory Loss, confusion Among Other Cognitive Symptoms of Alzheimer’s Disease, ”I have explained.
Lemborexant Prevents Tau Buildup, you reduce inflammatory Brain Damage
At the Study’s Conclusion, Researchers Found Treating the Mice with Lemborexant Helped to Prevent the Buildup of Tau in the Brain, Reducting The Inflammatory Brain Damage That Tau Buildup is Known To Cause In Alzheimer’s Disease.
“The detrimental increase of abnormal tau is closely associated with height had inflammaster Damage in the brain,” Parhizkar Said. “Research from Our Lab and Others you have demonstrated that inflammation in the brain is a significant contribution factor to the brain Damage Seen in neurodegenerative designs Like Alzheimer’s.”
“Concently, by Decreating Both the Abnormal Buildup of Tau and Inflamatory Damage, Lemborexant May Be Highly Effective in Safeguarding The Brain From The Sources of Injury,” She Addd.
Additionionally, Scientists Discovered That Mice Treated with the Sleep Aid Had at 30–40% Larger Hippocampus Volume Compared To Those Not Treated With The Medication.
“The Larger Hippocampal Volume Indicates reduced Brain Damage and Cellular Loss in Mice Treated With Lemborexant Compared to Those Given Vehicle Control,” Holtzman Said. “In the toup touc, Abnormal Tau Protein Continued to Accumulate in the Brain, Resulting in Cell Damage, Death, and Therefore Shrinkage of the Hippocampus Typically observed with neurodegeneration.”
Findings Consistency with Previous Research
MNT Also Had the Opportunity To Speak with Gary Small, MD, Chair of Psychiatry at Hackensack University Medical Center in New Jersey, About This Study.
Small, Who was not Involved in the Current Research, Commented that the Findings from This New Study Are Consistrent With Previous Research Linking Rest Partful Sleep With Better Cognitive Health.
“For Example, My Research Team Found That Sleep Quality Is Related To B Objective Measures of Substantion and Self-Awareness of Memory Decline, Suggesting that interventions for improving Sleep Quality May contributes not only to improving Reducting Memory Complaints, ”He To Told Us.
“Other Work has shown that restful sleep reduces brain amyloid and inflammation, which May explain Why Sleep Benefits Cognition. The Washington University Team Now Sheds Additionional Light on An an Underlying Link Between Insomnia and Cognitive IMPAIRMEMENT: ACCUMULATION OF TAU Protein, particularly in Brain regions controlling memory, ”Small Added.
According to Him:
“Nearly 40% of People in the Us Complain of Insomnia, Which Can Lead To Daytime Fatigue, Memory Issues, Difficulty Concentrating, Anxiety, Depression, Irritability, and Disprúthed Work and Social Activities. Available Medicines May Lead to dependence and posse Dizziness, Headache, Unusual Dreams, and Memory Problems.
Still, Small Cautioned That, While “(T) His Study is finding (…) Findings in An Animal Model Must Moverd for Clinical Trials of Human Volunteers to Determine The Safety and Effectiveness of This Potential Treatment.”
