- Late-Life Mood Disorders (LLMDS) Are mental health issues that first occur or recur at an Older Age.
- Past Research Shows That People with An Llmd May Be at A Higher Risk of Developing Dementia.
- A New Study Found That People with Llmds Have Larger Amounts of the Proteins Beta-Amyloid And Tau in their brains than Those with no late-Oset Mental Health Issues.
- Researchers Also Found thatSe Abnormal Brain Protein Levels Can Be detected Years Before Traditional Dementia Symptoms First Appear.
Late-Life Mood Disorders (LLMDS) Are Mental Health Issues, Such As Depression and Bipolar Disorder, That First Occur or Recur At an Older Age.
In Addition to Having An Impact On A Person Quality of Life, Past Research Shows That People With An Llmd May Be At A Higher Risk for Developing Dementia.
“We Often Encounter Cases In Clinical Practice Where Patients Who Develop Mood Disorders Later In Life – After The Age of 40 – eventually progress to dementia,” Keisuke Takahata, MD, PHD, Chief Research At The National Institute for Quantum Science and Technology in Japan, Toled Medical News Today. “
This has led to the shared clinical impression that Such Mood Disorders May, in Sumses, Represent Early Symptoms of Neurodegeneration. Previous postmortem Brain Studies Also Suggest that Depression and Dementia That Occur in Old Age Share Common Pathologies. However, The Underlying Pathophysiological Mechanisms (Have) Remained Unclear, ”I explained.
Takahata is The Co-Lead Author of A New Study Published in
Researchers Also Found thatSe Abnormal Brain Protein Levels Can Be detected Years Before Traditional Dementia Symptoms First Appear.
Beta-andoid, Tau Accumulation Found in LLMD BRAINS
For This Study, Recruited 99 Adult Study Participants-52 participants had the age of 40, and 47 participants acted as age-matched Healthy Controls.
Participants Received Positron Issussion Tomography (PET) Scans Using Two Different Tracers to detect the witness of Beta-and Tau in the brain.
Additionionally, Scientists Analyzed Brain Tissue Samples from 208 Autopsy Cases of Various neurodegenerative desire.
AT the Study’s Conclusion, Researchers Found that about 50% of participants with llmds had tau accumulation and 29% had amyloid deposits, versus 15% and 2%, respectively, in the control group.
“It suggests that mood disorders can emerge many years – over SEVEN ON AVANGE – BEFORE THE TYPICAL Symptoms of Dementia are pick up. In Other Words, Psychiatric Symptoms Such As Depression or Mania May Be the First Clinical Indicators of An ongoing neurodegenerative process. ACKNOWLEDGING THIS POSSIBILITY COULD HELP SHIFT THE CLINICAL MINDSET TO Considers in the Differential Diagnosis of New-Onset Mood Disorders in Older Adults. ”
– Keisuke Takahata, MD, PHD
Alzheimer’s Proteins detected 7 Years Before Traditional Symptoms
Takahata and His Team Also Discovered ThatSe Abnormal Protein Amount could be detected Years Before Traditional Cognitive Symptoms Appeared, With Mood Symptoms preceding cognitive or motor symptoms by an avege of 7.3 Years in Autopsy Cases.
“This Finding Highlights That Mood Symptoms Can Appear Well Before the Clinical Onset of Dementia, Subtim BY More than Seven Years. neurodegenerative dementias.
– Keisuke Takahata, MD, PHD
“Our Results Reinforce The Emerging Paradigm in Which Diagnoses of Alzheimer’s Disease (AD) and Non-Ad Tauopathies are Increasingly Reported by Objective Molecular Markers, Rather Than Relying Soly on Clinical Symptoms,” I have continued. “It also underscores The Potential Utility of Pet Biomarkers in Identifying AT-Risk Individuals at A Much Earlier Stage-Perhaps Even Before They Meet The Criteria for Mild Cognitive Impairment.”
“We Plan to Follow Individuals with Late-Life Mood Disorders Over Time Using Longitudinal Pet Imaging With Both Tau and Amyloid Tracers,” Takahata Added. “This Approach Will Allow US To Track The Progression of Pathological Changes and Relate Them To The Emergency of Cognitive Or Neurological Symptoms. By doing So, We Hope To Clarify Which Patients Are Truly In A Prodromal Phase of Dementia and Which May Follow Follow A More Slestable Psychiatric Course. “
Not Just About Treating Mood Symptoms Anymore
MNT Had the Opportunity To Speak with Richard A. Bermudes, MD, Board Certified Psychiatrist, Associate Physician in the School of Medicine Department of Psychiatry and Behavioral Sciences at The University of California, Davis, Chief Medical Offer of Brainsway, and Founder of Empathy Mindcare, About This Study, Who Commented The Findings Biking What’s Been Seen Clinically, and Fundally Reframs Late-Life Depression Treatment.
“This isn’t just about Treating Mood Symptoms Anymore – We’re Potentially Intervening in The Earliest Stages of Neurodegeneration,” Bermudes Explained. “The Finding That 50% of Late-Life Mood Disorder Patients Showed Tau Pathology Compared To only 15% of Healthy Controls Means We’ve Been Underestimating The Stakes.”
The importance of Early detection and diagnosis
“Early Detection transforms Everything in neurodegenerative disappearable Age 40 Signals Underlying Pathology Seven-Plus Years Before Cognitive Symptoms, We have an upset the Therapeutic Window. ”
– Richard A. Bermudes, MD
“We need to change clinical practice to embrace comprehensively Treatment Approaches Immedialy,” Bermudes Added. “The Evidence Supports Aggressive, Multimodal Intervention for Late-Life Depression, and We have demonstrated safety and remarkable efficient adults.”
New Findings Consistency with Previous Research
MNT Also Spoke with Gary Small, MD, Chair of Psychiatry at Hackensack University Medical Center in New Jersey, About This Study.
“Symptoms of Mood and Neurodegenerative Disorders Overlap, particularly for Older Adult. Untread Depression Increases The Risk for Dementia, and Patients with Alzheimer’s Disease and Other Forms of Dementia Show A High Rate of Depression.”
– Gary Small, MD
“BeSe New Findings Are Consistnts With Previous Research Showing A Link Between Amyloid And Tau Accumulation in the Brain and Mood Disorders,” Small Said. “NUMEROUS STUDIES INDE THAT EARLY DETECTION AND INTERVENTION IS AN IMPORTANT STRATEGY FOR NEURODEGENERATIVE DISEASES.
“Future Studies Using Amyloid and Tau Pet As Well As Oher Neurodegenerative Biomarkers in Both Mood and Cognitive Disorders Will Encarly Early Detection and Prevention Strategies,” I have add.
