• There are many ways to help keep the vascular system Healthy, Such as not smoking and keeping blood press at a healthy Level.
  • A New Study has found a link Between Certain Midlife Vascular Risk Factors – Specifically High Blood Pressure, Diabetes, and Smoking – and Risk for Dementia.
  • Scientists Report the Attributable Vascular Risk Factors Were Higher in B black and black participants, as well as non-carriers of the APOE ε4 Gene, which is Linked with an Increased Risk of Alzheimer’s.

The System vascular Refers to All The Blood Vessels That Run Through The Body. These vessels are in Charge of Moving Oxygen Throunge The Body and Remaving Waste Products.

There Are Modifiable Risk Factors That Can Help Keep Your Vascular System Healthy, Including Not SmokingStaying at a Healthy WeightExercising, Eating Right, and Keeping Your Blood Pressure and Cholesterol Levels Down.

If your vascular system is not functioning properly, it can increased your risk for vascular designs such aneurysm, peripheral artery disease, pulmonary embolism, and varicose veins.

Additionionally, Vascular Disease Can increased Your Chances of Developing Other Health Issues, Including Heart Attack and Stroke, and Can Worsen Kidney Disease.

Now, New Study Recently Published in the Journal Jama Neurology You have found a link Between Certain Midlife Vascular Risk Factors – Specifically High Blood Pressure, Diabetes, and Smoking – and Risk for Dementia.

Scientists Report the Attributable Vascular Risk Factors Were Higher in Both Self-Idesified Female And Black Participants, as Well As Non-Carriers of The APOLIPOPROTEIN ε4 (APOE ε4) gene.

Focusing on High Blood Pressure, Diabetes, and Smoking

For This Study, Rebecchers Analyzed Medical Data From About 7,700 participants from the atherosclerosis risk in communities (aric) Study, which RAN RAN FROM 1987-2020 with at 33-YEAR FOLLOW-UP. Participant Risk Factors Were Measured At Ages 45-54, 55-64, and 65-74 Years Old.

Focused on Three Vascular Risk Factors for This Study: High Blood Pressure, Diabetes, and Smoking.

“There’s Been Pretty Consistent Research for Decades that indicates the importance of these vascular risk risk factors in midlife (~ age 45-64 years) for elevating dementia risk, with less consensus on their associations in late-life (~ age ≥75 years),” Jason r. Smith, PhD, SCM, Who Was at the Time of the Study A Researcher in The Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health in Maryland and First Author of this Study, Told Medical News Today.

“The Prevalence of Vascular Risk Factors Also Remains High in Adults. So Vascular Intentions Factors Beginning as Early As Midlife Could Potentially Actt A Big Chunk of Dementia Risk,” He Said.

UP to 44% of Dementia Cases Linked To Vascular Risk Factors

UPON ANALYSIS, FOUND THAT BETWEEN REMOATHERS 22–44% OF DELMENTIA CASES REPORTED BY PARTICIPANTS by Age 80 ATTRIBUTABLE WERE TO MIDLIFE AND LATE-LATE-LIFE VASCULAR RISK FACTORS.

“That 22-44% of Population-Level Dementia Risk by 80 Years was attributed to at least one vascular Risk Factor from Midlife Through Early Late-Life (Ages 45-74 Years) Signals A Major Prevention Gap,” Smith Explained. “Clinical and Public Health Interventions Targeting Vascular Risk Beginning as Early As Midlife Could Delay or Prevent A Sizable Fraction of Dementia Risk by 80 Years.”

“The Burden of Dementia Remains High,” I have continued. “It has a heterogeneous presentation and pathology, so targeting risk factors that modifiable, more proximal more expression (including hypertension, diabetes, and smoking), and that could potentially impact more than one underlying process giving rise to dementia, is paramount to reduce Population-Level Dementia Risk. “

Higher Risk in Female, Black, Apoe Non-Carrier Participants

Additionionally, Scientists Found that the vascular risk atributable factor risk was Highest in Participants Who Self-Identified As female or Black, as Well as Those Not Carrying The Apoe ε4 Gene.

“Caution’s Warrad When Interpreting these Stratified Analysis, Given Wide.” Smith Said. “However, The Analysis Stratified by Abee Carrier Status suggests the vascular absolute contribution to dementia is Larger Among Those at Lower Genetic Risk for Alzheimer’s Disease.”

“And that the vascular contribution was Larger Among Those Racialized As Black Is Likely Due to a Higher Burden of Vascular Risk Factors in This Population,” I have continued. “More even and representative research is urgently Needed to Underestand the Potential of Vascular Risk Risk in Different Populams.”

“While this study is not design to evidence on individual-level dementia risk reduction, vascular optimal promoting Health as Early as Midlife could be vital for reducing population-level dementia risk by 80 Years,” Smith Added. “What’s Good for the Heart is Good for the Brain, and The Earlier Prevention Starts, The Better.”

Vascular Health needy for a healthy brain

MNT Spoke with Christopher Yi, MD, A Board Certified Vascular arise at Memorialcare Orange Coast Medical Center in Fountain Valley, CA, About This Study.

Yi Commented that This Study Reinforces an Increasingly Clear Message: Vascular Health is Brain Health.

“My first reaction was that the Findings Were Both Stiking and Practical – Nearly Half of Dementia Cases By Age 80 Could Be Linked To Modifiable Vascular Risk Risk Factors Like High Blood Pressure, Diabetes, and Smoking,” I have continued. “It’s specially remarkable that Late-Life Vascular Health Appeared Even More Strongly Associated With Dementia Risk Than Midlife Health, Which Challenges The Idea That’s It’s Too Late ‘To Make A Difference Appter Midlife.”

Yi Explained Hat Vascular Health Affects Dementia Risk Through severe interconnected mechanisms.

“High Blood Pressure and Vascular Disease Can Damage The Small Vessels That Supply The Brain, Leading to Chronic Ischemia (Lack of Oxygen) and Brain Tissue Damage,” He Detailed. “Silent Strokes and Microinfarcts Are Common in People With Uncontrolled Hypertension and Diabetes and Can Accumulate Over Time, Impairing Cognitive Function Without Obvious Warning Signs.”

“Vascular Risk Factors Promote inflammation and free radical damage, which contributes to neurodegeneration and Alzheimer’s pathology. (And) vascular chronic dysfunction can make the Blood-Brain Barrier Leaky, Allowing Harmful Substances to Enter The Brain and Accelerate Neuronal Damage. ”
– Christopher Yi, MD

For the Next Steps in This Research, Yi Said He was like to see more intervention trials, Risk Factor-Specific Analysis, Mechanistic Studies, and Policy Translation.

“Explore How before Findings Could Support More Aggressive Screening and Treatment of Vascular Risks in Primary Care, With Cognitive Outcomes in Mind,” I have added.