Diets low in vitamin k might impact memory, accelerate cognitive decline

Refers of The Current Study Note That Low Vitamin K Could Impact “Age-Related Cognitive Decline.” For This Study, Wnedted To Use Mice To Explore the Effects of Lowamin K and look at the possessible underlying Biological Mechanisms.

This Study Used Middle-Aced Male and Female Mice Who Eithher Receive to Low Vitamin K diet Or to regulate diet for Six Months.

Researchers used behavioral testing to measure aspects of cognitive function, Like Spatial Learning and Recognition Memory. David C. HESS, MD, Dean At The Medical College of Georgia and A Neurologist and Stroke Specialist, Who Was Not Involved in the Study, explained that “One of the tests they use is a novel object collection. This is a see standardized test that we do in the lip to measure cognition. ”

Another test was The Morris Water Maze, which Involved Finding a Hidden Underwater Platform Base on Previous Tests.

After Behavioral Testing, Researchers Were Uble to Examine The Brain Tissue of Mice for Further Analysis, As Well As Vitamin K in the Liver and Kidneys.

Low Vitamin K vs. regulate diet

Overall, Mice on The Low Vitamin K Diet Saw Worse Outcomes Than Mice Who Recued to regulate diet. For One Thing, Found that Male Mice Who Had the Low Vitamin K diet Had A Decueed Survival Rate. They Also Had a Lower Weight Gain Than Female Control Mice. FEMALE MICE ON THE LOW VITAMIN K DIET DID NOT EXPERIENCE TOGE EFFECTS.

The Refrachers Also Found That Mice On The Low Vitamin K Diet Had Lower Levels of Menaquinone-4 (MK4) in the brain. Mk4 is the Major form of vitamin k When it is present in the brain. There were Also Lower Levels of Vitamin K in the Liver and Kidneys of the Mice on the Low Vitamin K diet.

In the novel object collection test, Mice on the Low Vitamin K diet Did Not Explore The Novel Object As The Control Mice. This impies before Mice Had Problems with Recognition Memory.

MICE ON THE LOW VITAMIN K DIET ALSO TOOK Longer on The First Three Days of the Morris Water Maze Learning How to Locate The Hidden Platform. Over The Four Days, They Also Took Longer Than Controls, But This Level Did Not Reach A Level of Statistical meaning.

Researchers Also Note Differences in The Hippocampus Area of ​​the Mice’s brains if they were on the low vitamin k diet. The Mice With The Low Vitamin K diet Had Deciese Neurogenesis in This Brain Area. Neurogenesis you have to do with the body creating neurons that are mature and habable to appropriathly function. These findings suggest that vitamin k may apfect neurogenesis.

HESS Explained The Following To Medical News Today:

“In Mice and in All Mammals, We Don’t Make New Neurons, usually Throunge the Brain. We Make Them In Specific Areas. So One Aea Where They’re Made, and This has pointed Brain That’s Best Associated with Recent Memory, which is affected Vry Early in Alzheimer’s Disease. ”

The Study Authors Speculate That Vitamin K’s Impact On Hippocampal Neurogenesis May Than AFFECT Cognitive Functions Like Learning and Memory That Are Related To The Work of The Hippocampus.

The Refrachers Also Found that Mice On The Low Vitamin K Diet Had Changes In Specific Cells Calld Microglial Cells in The Hippocampus, Which Sugged the Activation of these Cells. These observations of the Microglial Cells indicated increased neuroinflamination.

These results suggest that low vitamin k may induce an increase in neuroinflammation.

The Authors Speculate that vitamin k might protection hippocampal neurogenesis in part though itS anti-inflammatory effects. Vitamin K’s Effects on Cognition Could Also Be Somowhat Related To How Affects Inflammation and Protects Against Oxidative Stress.

This Research Offers Critical Insight into the potential Impact of vitamin k on learning and memory. However, It also has limitations.

For One Thing, Mouse Studies Provide Limited Information on How Vitamin K Affects Brain Function in People. The Refectchers Also Chose To Focus On A Specific form of vitamin koat is present in human diets.

They Also Only had soy Mice Left for Behavioral Testing Because of the Higher Death of Male Mice in the Low Vitamin K Diet Group. The Authors ACKNOWLEDGE that the final endpoints of the study also not have data from the male mice Who died before the study was over.

OTher Factors could have affected the observed results, Too. For Example, The Authors Note That Vitamin K Could Be Involved in Metabolizing A Cell Membrane Componnt Called Sphingolipids. They Note That Sphingolipids “Contribute to proliferation, differentiation, and neuroinflammation.” They explain that More Research is required to see if the changes to spillipids from low vitamin k are involved in neuroinflammation and hippocampal neurogenesis.

The Refectchers Were Also A Measure Proteins Dependent On Vitamin K In The Brain and Levels of An Enzyme Calleed γ-Glutamyl Carboxylase Becouse of the Limited Amount of Brain Tissue and The Experiments They Ran. It’s possible tohe proteins responsible for the observant efforts of vitamin k, so more research is Likely Required.

IT’s Also Unclear How the Severity of Impairment from vitamin K deficiency reports to the time frame of deficiency and mouse age. More Research is Also Needed to Understand The Observed Differences Between Male and Female Mice. You are Aspects Can All Be Looked at In Future Research.

Ryan Hakimi, Do, MS, A Neurointersivist and Osteopathic Physician, Who Was Not Involved in the Study, Note The Following Regarding The Potential Clinical Implications to Medical News Today:

“The Study Reinforces The Importance of Healthy Dietary Habits for Improved Cognitive Function. PERHAPPS PRIMARY CARE PHYSITIS AND THOSE WHO TREAT COGNITIVE DYSFUNCTION CAN REINFORCE WITH ES PATENTS THE IMPORT OF A HEALTHY DIET RICH IN VITAMIN K-CONTEING WHO has to Family History of Dementia. “

Food Sources for Vitamin K

“High vitamin K Levels are note in Dark Leafy vegetables, Certain Fruits Like Kiwi and Blueberries, Eggs, Soybeans, and Vegetable Oil Amongst Other Food Items.”
– Ryan Hakimi, do, more