• There Is Currently No Tool For Predicting How Quickly Early Stage Alzheimer’s Disease Will Progress.
  • New Study has identified with simple Blood test used to measure insulin resistance that may also hello doctors determine which People with Early Stage Alzheimer’s Disease Are Most Likely to Experience Rapid Cognitive Decline.
  • The Test Found That Higher Insulin Resistance indicated quicker deterioration in cognitive decline.

Researchers Estimate That About 69 Million People Around the World Are Living With Prodromal Alzheimer’s Disease, Or Early Stage Alzheimer’s Disease.

People in the Earliest Stage of Alzheimer’s Disease Begin to Experience Sub Mild Cognitive Impairment That May Affect Their Memory and Ability to Complete Tasks and Communicate.

Past Studies Show That Detecting Alzheimer’s Disease in its Earliest Stage Allows Currently Available Medications and Lifestyle Changes to Be More Effective in Helping to Slow Down Down Disease Progression.

“Alzheimer’s (Disease) Begins Silently, off decades beforare symptoms appeal, and so detecting risk early is essential to slow or alter the ease cours Brescia and for the neurology unit in the department of continuity of care and frayty at aff Medical News Today.

“Current tools can diagnose the ease, but they don’t always predict how fast it will progress. Identifying individuals at Higher Risk of Rapid decline (c) ould (Lifestyle), ”She Said.

Gumina Is Part of the Research Team for A Study Recently Presented at the European Academy of Neurology (EAN) Congress 2025 that has identified the simple Blood Test Used To Measure Insulin Resistance That May Also Help Doctors Determine Which People With Early Stage Alzheimer’s Disease Experience Rapid Cognitive Decline.

The Findings of the Study Are Yet To Be Published in A Peer-Reviewed Journal.

The Tyg Index Test For Alzheimer’s

For This Study, Refracchers Analyzed Medical Records from 315 adults with an average age of about 70 that did not have diabetes. Two Hundred of the Study Participants Had Received Biological Confirmation They Had Alzheimer’s Disease.

ALL STUDY PARTICIPATIONS REVIVED INSULIN RESISTANCE ASSESMENT USING A TEST CALLED THE TRIGLYCERIDE-GLUCOSE (TYG) INDEX, with a clinical follow-up Three Years late.

“The Tyg Index is a Validated Marker of Insulin Resistance, A Condition OFTEN SEEN IN PREDIANTS OR METABOLIC SYNDROME,” GUMINA EXPLAINED. “It Combines Triglycerides and Fasting Blood Glucose, Two Common and Non-Invasive Blood Values. (It is) Easy to calculate and already Available in Routine Labs.”

Higher Tyg Index Results Predict Quicker Cognitive Decline

At the Study’s Conclusion, The Research Team Found That When Grouming Study participants by their tyg Index Results, Those in the Highest Tyg Index Group Experienced Quicker Deterioration in Cognitive Decline The Those With Lower Tyg Index Results.

4-Fold Higher Risk

“This finding is significant scholars Risk of Rapid Cognitive Decline Compared to Those With Lower Tyg Levels.
– Bianca Gumina, MD

“The Tyg Index is a Low-Cost, Widely Available Tool that could be easily integrated into routine clinical practice to flag patients at higher risk of rapid decline,” She continues. “By identifying these individuals Early, Clinicicians Could Prioritize Them for Closer Monitoring, Lifestyle Interventions, Or Even Enrollment in Clinical Trials, maybe individualization Phenotypes of the disease. It also supports The Development of Metabolic-Based Treatment Strategies, Potentially Paving The Way For Therapies Targeting Insulin Resistance to Modify Disease Progression. ”

As for the Next Steps in This Research, Gumina Said the Research Group is Currently Exploring Whether The Tyg Index Also Corlates With Neuroimaging Biomarkers of Brain Degeneration.

“The Next Goal is to Integrate Metabolic Profiling with Genetic and Imaging Data to Refine Risk Models and Guide Early, Personalized Interventions,” She Added.

New Variable potential for Alzheimer’s Progression Predictions

MNT Spoke with Rehan Aziz, MD, Geriatric Psychiatrist at Jersey Shore University Center in New Jersey, About This Study.

Aziz Commented that has thought This was a very interesting study invoke a new variable to consider when working with patients in the Early Stages of Alzheimer’s Dementia, specially as it may predict Who is Likely to decline faster.

“Accurate Progression prediction is crucial for multiple reasons,” I explained. “It Empowers Families to Make Reported Decions About Care Planning, Financial Arrangements, and How to Prioritize Quality Time Together. Clinically, It Helps Us Identify Patients Who Need More Intensive Monitoring and Earlier Intervention.”

“With New Disease-Modifying Treatments Like Aducanumab and Lecanemab Becoming Available – Treatments That Carry Real Risks Including Brain Swelling and Bleeding – We Urgently Need Better Ways to Identify Which Patients Are Most Likely To Benefit From AgragSive Treatment versus Those Who Might Have Slower Progress, “Aziz Continued.

“This metabolic marker could help us customizates the risk-benefit calculation for each patient, Reninging We’re Offering before Powerful But Potentially Risky Therapies to Those Who Need Them Most While Protecting Slower-Progressing Patients From UnneCery Exposure. “
– Rean Aziz, MD

Aziz Said He’d Like to See This Study’s Results Validated in Larger Populans.

“We Also Need Longer Follow-Up Studies to see If This Predictive Power Holds Over Five To 10 Years,” I have continued. “I’m particularly intersted in whether interventions targeting insulin resistance-like lifestyle modifications or medications like metformin-could today slow progression in high-Tyg patients. Risk Stratification Tool. ”

More Information on How Alzheimer’s Progresses

MNT Also Spoke with Peter Gliebus, MD, Director of Cognitive and Behavioral Neurology at Marcus Neuroscience Institute, Part of Baptist Health South Florida, About This Research.

GLIEBUS COMMENTED THAT HE FOUND THE STUDY BOST FASTINTING AND HIGHLY APPLIBLE TO DAILY CLINICAL PRACTICE.

“As Clinicians, We Frequently Encounter Questions from Patieves and Their Families, Such As, ‘How Quickly Will It Worsen?’ – And we offer Don’t Have a Definitive Answer,” I explained.

“The prospect that simple, cost-confective marker like the tyg index could predict progression in alzheimer’s disase of is extremely finding.

“Early-Stage Alzheimer’s, Specially During the Mile Strategies.
– Peter Gliebus, MD

“As New Treatments Are Developed, Timing and Patient Stratification Will Be Essential – Tools Like The Tyg Index May Play A Crucial Role In That Process,” I have added.