Intermittent Fasting May Help Prevent Blood Clots

Refers of the Current Study Wanted To Understand More About How Intermittent Fasting Fects Components of Blood Clotting. Intermittent Fasting Involves Limiting or Noting Food During Certain Time Windows While Eating Normally at Other Times.

Blood Clots Happen Through A COMPLEX PROCESS THAT INVOLVES PLALET Activation and, Ultimately, The Formation of A Thrombus or Blood Clot. Palelet Activation Involves to Distinct Change and Secretion by Small Blood Cells street Palelets. Palelet Activation and Blood Clot Formation Can Subtimes Be A Problem, Such As When Subone Experiences to Heart Attack.

This Research Involved People and Mice.

Researchers recruited 160 participants Who Had Coronary Artery Disease. They excluded participants Who Had Been Taking Antiplatelet Medications for The Last Two Weeks, As Well As Participants With Certain Conditions Like Anemia Or Heart Failure. Participants were Taking Aspirin.

They have randomly divided participants into Two Groups: One Participated In Intermittent Fasting While The OTher Followed An ad libitum diet This Intervention Time Lasted Ten Days. Refers Collected Blood Samples Before and After the Intervention.

The Intervention was similar for the mice, with One Group Doing Intermittent Fasting While The Other Group Just Had An an ad libitum diet

Overall, Saw Distinct Benefits Related to Intermittent Fasting. The Results from Analysis of the Mice and the Blood of Human Participants Indicated ThatTtent Fasting Helps Inhibit Palelet Activation and Blood Clot Formation.

Refrachers Also observed that intermittent fasting inhibited plalet aggragation in human participants and mice, Another Component that ultimately leads to Blood Clot Formation.

FURTER MICE ANALYSES REVOLED THAT THE LIKELY KEY METABOLITE AFFFECTING BLOOD CLOTTING PROCESSES WAS INDOLE-3-PROPIONIC ACID (IPA). Refers detected IPA in Higher Levels in the Serum for the People and Mice Who Had Dooked in Intermittent Fasting.

Examination of Human Participant Samples And Ipa Further Supported That “IPA Directly Inhibits Human Palelet Activation In vitro.

To performance Additional Analysis in Mice, Refecchers Also Gave Mice Injection of IPA, and also Mice Experienced prolonged clotting time in a Way that was similar to 5 mg/kg dose of the antithombotic Drug Clopidogrel. They Found The Results Were Even More Significant in Mice Who Receive Both IPA and Clopidogrel.

FURTER ANALYSIS OF MOUSE PLAELETS ALSO SUGGESTESED THAT IPA ACTS ON A SPECIFIC PATELET COMPONT CALLED THE PREGNANE X RECEIVER TO HAV ITS EFECT ON PLAET Activation. Findings from Human and Mouse Samples suggesta that the effort of IPA on Palelet Activation Is Also Related To Pregnane X Receiver Signaling Pathways.

Refectchers Noted That IPA is a metabolite that is produced in the gut, and in mice, it is mainly produced by a type of bacteria street C. Sporogenes. MICE WHHO DID INTERMITTENT FASTING HAD HIGHER LEVELS OF C. Sporogenes. ADDITIONALLY, ANTIBIOTIC TREATMENT GREATLY MINIMIZED THE ANTIPLELET AGGGATION IMPACT OF INTERMITTENT FASTING IN MICE.

MICE ALSO I PLUE TO BROTH CONTATING C. Sporogenes, and also Mice Had Notable Higher Ipa Levels. Mice Who Received C. Sporogenes and Mice Who Received IPA Had Longer Clotting Times and a Lower Palelet Aggregation Ratio. Ultimately, The Results Suggest Intermittent Fasting Affects Blood Clotting Through A Metabolite Produced in the Gut.

Researchers Also Tested The Response of Mice To Experience cerebral ischemia, A Cutting off of Blood Flow to the brain, and myocardial Ischemia, A Cutting Off of Blood Flow to the Heart, Both followed by A Return to Blood Flow. They Found that Mice Who Had Done Intermittent Fasting Experience Better Heart and Brain Outcomes Than Mice Who Had Not.

Christopher Yi, MD, A Board-Certified Vascular arise at memorialcare orange coast medical center in Fountain Valley, ca, who was not involved in the study, commented with his thoughts on the findings to Medical News Today:

“This is a see Interesting Study That Suggests A Novel Non-Pharmacologic Approach To Managing Thrombosis Risk. (I) Pa Showed Antithombotic Efficacy comparable to clopidogrel, which is a commonly used antiplelet medication. Together, Both can act synergistically to reduces plalet aggragation and low thrombosis risk, Important factors in the treatment of vascular and cardiovascular ease. This can potentially provides novel Therapy Pathway for The Physicans, which is very exciting. ”

While Part of this Research Included People, It Also Used Mice, Meaning That More Research is Needed to Fully Understand the Impact On People and Whether it Indeed comparis to the results found in mice.

More Research Is Also Required to Confirm The Findings, The Underlying Mechanisms that Sough To Identify, and OHER POSIBLE CONTRIBUTING FACTORS.

The Work that Did Include Human Participants Also Had Limitations. For One, The Intervention Time Was Only Ten Days, So It Does Not Address The Long-Term Effects of Intermittent Fasting on People. It also looks at a spee a spect of intermittent fasting, so it is a unclear if the efforts would Be the Same with other intermittent fasting patterns.

Additionionally, While participants were instruct to follow the intermittent fasting pattern, it’s possible that participants did not full adhere to the instructions and participants could not be blinded to the intervention. It’s Also Likely that Did Not Account for Celerin Factors That Could Have Affected The Observed Results.

INFORMATION REGUDING PARTICIPANTS IN THE REPORT WAS LIMITED. Future Research Coud Work with Additionional Groups to include Wide Variety of Individuals, Likely Including Greater Diversity.

The procedures and methods used, Such as using different Types of Mice or Indole, Could have affected the results, so replicating the findings and behavioral addionional Research may be helpful.

One Author Note to Conflict of Interest But “was Blinded from Reviewing or Making Decions from The Manuscript.” Additionionally, Received Study Funding From Several Grants.

Refracchers ACKNOWLEDGE THAT MORE REESARCH IS REQUQUEQUED REGUARDING INTERMITTENT FASTING AS A POTENTIAL TREATMENT FOR CORONARY ARTERY DIEW.

This Research Impies Another Potential Benefit of Intermittent Fasting, Even Though Future Research Will Need to Confirm The Findings.

Yi Note The Following Regarding The Study’s Clinical Implications:

“Intermittent Fasting Could Be a Lifestyle-Based Intervention to reduce cardiovascular risks in patients Who are at high risk of stroke and heart attack. It can provide an adjunct therapy to the management of cardiovascular disassembly, to go along with current medications progressable. ”

It Further Highlights The Role of Gut Health and How May influence oher Areas of Bodily Function. People Can Work With Their Doctors and Specialists to find the Best Strategies for Intermittent Fasting and Promoting Gut Health.

As Patrick Kee, MD, PHD, A Cardiologist With Vital Heart & Vein, Who Was Also Not Involved in the Study, Note to Medical News Today That Following to Healthful Diet Was Important, Along With The Potential Benefit Effects of IntermitTtent Fasting.

“Intermittent Fasting Not Only Promotes to Healthy Gut Bacteria Population, As Demonstated in This Study, But Also Leads to Signanant Weight Reduction, Improved Diabetes Control and Insulin Sensitivity, and reduced inflammation in the body. To Further Enhance Gut Health, to Diet Rich in Fiber, Leafy Greens, Legumes, and Yogurt Provides an optimal Environment for beneficial bacteria to Thrive. ”
– Patrick Kee, MD, Ph.D

“Conversaly, Avoiding pro-inflammatory diets, Such as thhue containing red meat, saturated fat, ultra-processSed Foods, and alcohol, Helps Prevent the Accumulation of Harmful bacteria that may generate generate undesirably substances Cardiovascular Health,” I have add. “