• Dementia Affects Millions of People Worldwide, and Numbers are Increasing Rapidly.
  • One Factor That May increased The Risk of Dementia Is High Levels of Blood Cholesterol.
  • Now, A Study you have found that low levels of ldl-c, or ‘bad’ chollesterol, May reduces the Risk of Developing Dementia.
  • Statins, to Cholesterol-Lowering Medication, Could reduces The Risk of Dementia Further in People with Low LDL-C.

Cholesterol Performs Many Essential Functions Within The Body, Including Building Cell Membranes, Production Steroid Hormones and Helping Create Bile in the Liver.

However, Too Much Cholesterol-Particularly Low-Density Lipoprotein Cholesterol (LDL-C)-Can Lead to Health Problems, Such As Cardiovascular Disease.

Cholesterol Levels May Also Affect A Person’s Risk of Developing Dementia But Study Findings are inconsistent. Sub studies suggest that Higher Levels have to Protective Effect; Others Maininin That Dementia Risk is not Linked to High Cholesterol.

Another Study Has Found Vray Little Association Between LDL-C and Dementia Risk.

A New Study By South Korean Researchers have found that People with Low, but not Extremely Low, LDL-C Levels have a reduced Risk of Developing Dementia, and This Decree Appears to Be enhanced If they take chollesterol-lowering statins.

The Study Is published in the BMJ Journal of Neurology, Neurosurgery and Psychiatry.

Emer MacSweeney, MD, CEO and consultation neuroradiologist at re: cognition health, who was not involved in This Study, explained for Medical News Today That:

“The Study Reinforces The Importance of Lipid Management in Overall Health, Including Cognitive Function. It Also Highlights The Complexity of Ldl-C’s Role In Dementia, Suggesting That Optimal Levels Exist rather than a ‘Lower is always better’ Approach. acese Findings Should Be interpreted with Caution Due to the observational nature of the study.

Low LDL-C LINKED TO Reduced Dementia Risk

The Refers Analyzed Outpatient Data, Collected Between 1986 and 2020, From More than 12 Million People At 11 Medical Centers in South Korea.

United States Government Guidelines State that to Healthy Level of LDL-C IS Under 100 Milligrams per deciliter (mg/dl).

After an initial analysis, The Researchers divided their final sample into two Groups: 108,980 People with LDL-C Greater than 130 mg/dl, and 108,980 with LDL-C Under 70 mg/dl. All were followed for 180 days after testing, for comparison.

They remembered Two Outcomes-to Primary Outcome of All-Cause Dementia, and a Secondary Outcomo of Alzheimer’s Disease.

The Refectchers Replicated Their Analysis with A Subset of Patients Who Had Been prescribed Statins Before Inclusion in the Study, dividing Them into Three Groups by LDL-C Levels: Less than 55 mg/dl, Less Than 70 mg/dl, and Greater Than 130mg/dl.

PEOPLE WITH LDL-C LEVELS BELOW 70 mg/dl HAD A 26% LOWER RISK OF ALL-CAUSE DEMENTIA AND A 28% LOWER RISK OF ALZHEIMER’S DIEX

AT LDL-C Levels Below 70 mg/dl, The Reduction in Dementia Risk Diminished. People with LDL-C at 55 mg/dl Had Only 18% Risk reduction, and below 30 mg/dl, There was no reduction in dementia risk at all.

MacSweeney Told MNT: “This is an interesting observation indicating a potential threshold effect, where reducing ldl-c Beyond to Celerin Point does not further improvisive cognitive outcomes. It it aligns with previous prior to the indicating that WHILE HIGH LDL-C IS HARMFUL, EXCESSIV ADDITIONAL PROTECTIVE EFFECTS. “

And David Gill, MD, A Neurologist at The University of Rochester Medical Center, similarly not Involved in the Study, explained Further That:

“High Levels of LDL-C Are Associated with Higher Rates of Vascular Disease Such as Coronary Artery Disease in the Heart and Lowering Thue Levels to a Point is Associated With Reduled Risk of Vascular Disease But There Does Not Ans Level and Extremely Low Levels May Actually Be Harmful. “

Statins may amplify benefits of Low LDL-C

Statins Are Medications used to Help Lower Blood Cholesterol Levels, to reduce The Risk of Heart Attacks and Strokes. This Study Suggests That They Might Also reduces The Risk of Dementia.

In People with LDL-C BELOW 70 mg/dl, Statins Were Associated With A Further 13% Reduction In Dementia Risk, and A Further 12% Lowering of Alzheimer’s Risk, Combase With Nonusers. The Researchers Found that Statins Slightly Decueed Risk in Those with Higher LDL-C Levels, But Had No Effect in Those with LDL-C Levels Below 55 mg/dl.

However, Gill Cautioned That, “S (I)

“This is an important distinction beset there is limited evidence that statin uses is associated with less risk of dementia spits many studies looking at This Risk,” He noted. “This Study is Yet Another Study to Add To this List of Studies That Suggest There May Be an Association Between Statin Use and a Lower Risk of Dementia.”

“In general, I recommend statin or oher lipid lowering medications be used action to recommend guidelines for prevention and treatment of coronary artery desaase, Stroke and peripheral vascular vascular desa That Statin Medications do not reduces the Risk of Dementia and Have their Own Risks. ”

– David Gill, MD

WHY MIGHT LOWER CHOLLESTEROL AND STATINS REDUCE DEMINIA RISK?

The Authors of the Study State That Higher Levels of LDL-C Lead to Inflammation, Oxidative Stress and an Imbalance in Brain Cholesterol Homeostasis, All of which are implicated in the Development of Dementia.

Conversley, Low LDL-C Reduces The Risk of Atherosclerosis and Cerebrovascular Disease, Which Known Risk Factors formentia.

Statins Enhance The Function of Endothelial Cells That Line Blood Vessels, Reduces Neuroinflammation and Regulate The Metabolism of Beta-andoidwhich forms the plaques that are Characterist of Alzheimer’s Disease.

“This suggests that statins may have neuroprotective Effects Beyond Simply Lowering LDL-C, Possibly Through an anti-inflammatory or vascular mechanism,“ Macsweeney Explained Further.

“However,” She Cautioned, “The Effect Size Was Modest and More Research is Needed to Confirm Causation.”

Keep LDL-C Low To Enhance Health

Although This Study Cannot Provuat Lower LDL-C Decias Dementia Risk, It Does Help Protect Cardiovascular Disease, So People Are Advised To Keep their LDL-C Levels Below 100 mg/dl.

MacSweeney Advised:

“To Maintain Healthy LDL-C Levels While Optimising Cognitive Benefits, It Is Advised To Follow to Heart-Healthy Diet Rich in Fruits, Vegetables, Whole Grains, and Healthy Fats (EG, Olive Oil, Nuts, Fatty Fish).”

She Also Advocated Enrolling in Regular Physical Activity, Avoiding Smoking and Limiting Alcohol Consumption. In Adionion, She recommended that People Manage Their Weight and Control Conditions Like Hypertension and Diabetes, and Only “Considers Statin Therapy if Clinically Indicated, under Doctor’s Guidance.”