• Past Studies Show that Certain Lifestyle Changes – Such As Getting More Physical Activity – May Help Lower A Person’s Risk for Alzheimer’s Disease Or Slow ITS PROGRESSION.
  • A New Study Sheds Light On How Physical Activity Helps Protect the Brain From Alzheimer’s Disease on a Level Cellular.
  • Scientists Believes Best Findings May One Day Lead to New Prevention and Treatment Strategies for Alzheimer’s Disease.

Researchers Estimate That About 32 Million People Glory Live With Alzheimer’s Disease – A Type of Dementia That Affects a Person’s Ability to Think, Communicate, and Remember.

While There Is Currently No Cure For Alzheimer’s Disease, Past Studies Show That Certain Lifestyle Changes May Help Decrease Person’s Risk for The Disease Or Slow Down ITS PROGRESSION.

One of these Main Lifestyle Changes is Physical Activity. A Study Published in April 2025 reported that increasing Physical Activity in Middle Age May Help Protect the Brain from Alzheimer’s Disease. A STUDY PUBLISHED IN MAY 2025 SAYS OLDER ADULS WHO SIT Less May Lower their Risk for the Condition.

Now, New Study Recently Published in the Journal Nature Neuroscience Sheds Light on How Physical Activity Helps Protect the Brain from Alzheimer’s Disease on a Cellular Level.

Scientists Believes Best Findings May One Day Lead to New Prevention and Treatment Strategies for Alzheimer’s Disease.

What is Snrna-Seq?

For This Study, Refrachers used Technique Calleed Single-Nuclei Rna Sequencing (Snrna-Seq).

“Single-Nuclei RNA Sequencing (Snrna-Seq) is a Technique That Allows (US to) Analyze Gene Activity By Examining The RNA Inside on A Cell by Cell Level, Giving Us Precise Information about the Activation State of Each and Every Single Cell in The Tissue Examined, ”Christiane D. Wrann, DVM, PHD, to Neuroscientist and Leader of the Program in Neuroprotecction in Excerise at The Mass General Brigham Heart and Vascular Institute and the McCance Center for Brain Health at Massachusetts General Hospital, and senior author of this study, explained to Medical News Today.

“We used this sophisticated technology to examine How Exercise Reshapes (The) brain in an important region in the brain of mouse models for Alzheimer’s Disease,” Wrann Added.

Exercise Changes Activity in Microglia, nvas in the hippocampus

Scientists Focused on The Hippocampus of the Brain, Which is Responsible For Making New Memories and Keeping Old Uones, As Well As Processing Emots and Learning New Information.

Using a Mouse Model of Alzheimer’s Disease – That were lateified in Human Alzheimer’s Disse Microgliaas well as a Specific Type of Neurovascular-Associated Astrocyte (NVA).

NVAS ARE CELLS ASSOCIATED WITH THE BRAIN’S BLOOD VESSELS THAT HELP MAK SOUTH THE BRAIN AUGUES ENOUGHGEN AND IS AN IMPERTANT PART OF THE Blood-Brain Barrier.

“(Our Findings Mean) That Exercise Can Remodel The Importent Cell Types On The Transcripctional/Gene Expression Level, Which Likely Increases Their Neuroprotective Properties.“ It (is) One Example, How On The Molecular Level Excerise Can Improve Brain Cells In Alzheimer’s In Alzheimer Hopefully Rendering Them More Functionally. ”
– Christiane D. Wrann, DVM, PHD

ATPIF1 Gene Helps Create New Neurons

Addionione ATPIF1 As an important regulator to create new neurons in the brain.

“ATPIF1 is a mithochondrial protein that regulaters Cellular Energy Production AKA – a gene that regulaters energy metabolism,” Wrann Detailed. “Research has shown that stimulating neurogenesis can protects Cognitive Decline In aging or Alzheimer’s Disease. In Our Study, We Show that atpif1 is an important regulator of neurogenesis. “

“Exercise is important for your Brain Health – please Keep Exercising to Protect Your Brain,” She continues. “Alzheimer’s Disease is incurable at the moment. There are Smart and dedicated Scientists Working on Finding Innovative Treatment Options.”

“This work not only sheds light on how exercise benefits the brain but als Uncverse potential Cell-Specific targets for future Alzheimer’s therapies,” Nathan Tucker, phd, to biostatistics at Suny Upstate Medical University and Co-Senior of The Study Said in A Press Release “Our Study Offers A Valuable Resource for the Scientific Community Research Alzheimer’s Prevention and Treatment.”

DeEper Underestanding of How The Brain Responsps to Exercise

MNT Also Had the Opportunity To Speak with Gary Small, MD, Chair of Psychiatry at Hackensack University Medical Center in New Jersey, About This Study.

Small Commented that This Study’s Findings Are Consistnts With The Well-Documented Link Between Physical Activity and Brain Health, including its Role in Risk the Risk of Alzheimer’s and of Slowing ITS PROGRESSION IN PEOPLE WHO ALREADY SUFFER SUFFER FROM.

“While the basic conclusion that exercise is important to brain health is not new, these new findings showing the impact of Physical Activity on Key Brain Cells Such As Microglia and Neurovascular-Associated Astrocytes Exercise, ”I have explained.

“Astrocytes and microglia play a crucial role in that initiating and regulating the inflammatory responsibility. Thus, these results further elucidate the link Between HeightTented Brain Inflammation and Cognitive Decline,” He Said.

“Brain Health Has A Strong Influence on Our Quality of Life. Cognitive Decline Affects Not Just The Physical and Behavioral Health of the Patient, But also you have an impact on their caregivers and all who AGING.
– Gary Small, MD

“The More We Understand How Cognitive Decline Occurs, and What Can Change The Course of ITS Development and Progression, The More Opportunities there are to find Ways To Treat It,” Small Added.